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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prognostic significance of E-cadherin expression and peripheral blood micrometastasis in gastric carcinoma patients
Annals of Surgical Oncology, Volume 17, No. 11, Year 2010
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Description
Background: The primary objective is to evaluate the prognostic value of E-cadherin (E-cad) expression and peripheral blood micrometastasis (PBMM) in gastric carcinoma. Secondary objective is to study the association between these 2 markers and the clinicopathological features of the patients. Materials and Methods: This study took place at Ain Shams University Hospitals. A total of 30 patients with histologically proven gastric adenocarcinoma after curative surgical resection were enrolled in this study. E-cad expression was assessed in tumor tissue samples. Before the start of adjuvant chemoradiotherapy, fresh blood samples were collected to detect PBMM as indicated by cytokeratin18 mRNA expression using real-time quantitative polymerase chain reaction (RQ-PCR). Results: Both abnormal E-cad expression and PBMM were significantly associated with lymph node metastasis, TNM stage, and lymphatic invasion. Moreover, PBMM was significantly associated with poor tissue differentiation and vascular invasion (P < .05). We found strong agreement between E-cad expression and presence of PBMM (P = .001). Both cases with altered E-cad expression and cases with positive PPMM showed shorter relapse-free survival (RFS) (P = .003 and <.001, respectively). Cox regression analysis showed that positive PBMM was independent predictor factor for relapse (hazard ratio [HR] = 6.14; 95% confidence interval [95% CI] = 1.06-35.63; P = .04). Cases with positive PBMM showed shorter overall survival (OS) (P = .001). Conclusions: In conclusion, loss of normal E-cad expression in gastric cancer showed a close correlation with the presence of PBMM. PBMM was associated with poor RFS independent of other clinicopathological features. Additionally, detection of PBMM was a significant indicator of OS, and intensive chemotherapy seems to be indicated for these patients. © 2010 Society of Surgical Oncology.
Authors & Co-Authors
Saad, Abeer Attia
Egypt, Cairo
Ain Shams University
Awed, Nahla M.
Egypt, Cairo
Ain Shams University
Abd Elkerim, Nashwa N.A.
Egypt, Cairo
Ain Shams University
El-Shennawy, Dina A.
Egypt, Cairo
Ain Shams University
Alfons, Marian Adel
Egypt, Cairo
Ain Shams University
Elserafy, Mohamed E.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Darwish, Yasser Wagih
Egypt, Cairo
Ain Shams University
Barakat, Eman Mahmoud Fathy
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Ezz-Elarab, Sahar S.
Egypt, Cairo
Ain Shams University
Statistics
Citations: 36
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1245/s10434-010-1151-8
ISSN:
10689265
e-ISSN:
15344681
Research Areas
Cancer
Environmental
Health System And Policy
Study Approach
Quantitative