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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Burden of celiac disease in the Mediterranean area
World Journal of Gastroenterology, Volume 17, No. 45, Year 2011
Notification
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Description
AIM: To estimate the burden of undiagnosed celiac disease (CD) in the Mediterranean area in terms of morbidity, mortality and health cost. METHODS: For statistics regarding the population of each country in the Mediterranean area, we accessed authoritative international sources (World Bank, World Health Organization and United Nations). The prevalence of CD was obtained for most countries from published reports. An overall prevalence rate of 1% cases/total population was finally estimated to represent the frequency of the disease in the area, since none of the available confidence intervals of the reported rates significantly excluded this rate. The distribution of symptoms and complications was obtained from reliable reports in the same cohort. A standardized mortality rate of 1.8 was obtained from recent reports. Crude health cost was estimated for the years between symptoms and diagnosis for adults and children, and was standardized for purchasing power parity to account for the different economic profiles amongst Mediterranean countries. RESULTS: In the next 10 years, the Mediterranean area will have about half a billion inhabitants, of which 120 million will be children. The projected number of CD diagnoses in 2020 is 5 million cases (1 million celiac children), with a relative increase of 11% compared to 2010. Based on the 2010 rate, there will be about 550 000 symptomatic adults and about 240 000 sick children: 85% of the symptomatic patients will suffer from gastrointestinal complaints, 40% are likely to have anemia, 30% will likely have osteopenia, 20% of children will have short stature, and 10% will have abnormal liver enzymes. The estimated standardized medical costs for symptomatic celiac patients during the delay between symptom onset and diagnosis (mean 6 years for adults, 2 years for children) will be about €4 billion (€387 million for children) over the next 10 years. A delay in diagnosis is expected to increase mortal ity: about 600 000 celiac patients will die in the next 10 years, with an excess of 44.4% vs age- and sex-matched controls. CONCLUSION: In the near future, the burden of CD will increase tremendously. Few Mediterranean countries are able to face this expanding epidemic alone. © 2011 Baishideng. All rights reserved.
Authors & Co-Authors
Greco, Luigi G.
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Timpone, Laura
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Abkari, Abdelhak
Morocco, Casablanca
Hopital D'enfants, Uir Casablanca
Abu-Zekry, Mona A.
Egypt, Giza
Cairo University
Attard, Thomas Mario
Malta, Msida
L-università Ta' Malta
Bouguerrà, Faouzi
Tunisia, Tunis
Université de Tunis el Manar, Hôpital D'enfants Béchir Hamza de Tunis
Cullufi, Paskal
Albania, Tirana
University Hospital Centre Tirana
Kansu, Aydan
Turkey, Ankara
Ankara Üniversitesi
Mičetić-Turk, Dušanka
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Mišak, Zrinjka Matek
Croatia, Zagreb
Childern's Hospital Zagreb
Roma-Giannikou, Eleftheriá S.
Greece, Athens
National and Kapodistrian University of Athens
Shamir, Raanan
Israel, Tel Aviv-yafo
Tel Aviv University
Terzić, Selma
Bosnia and Herzegovina, Tuzla
University Clinical Center Tuzla
Statistics
Citations: 49
Authors: 13
Affiliations: 12
Identifiers
Doi:
10.3748/wjg.v17.i45.4971
ISSN:
10079327
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study