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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Duration of antibiotic therapy for ventilator-associated pneumonia: Comparison of 7 and 10 days. A pilot study
Annales Francaises d'Anesthesie et de Reanimation, Volume 28, No. 1, Year 2009
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Description
Objective: To compare the efficiency of a 7-day antibiotics regimen with a 10-day regimen for ventilator-associated pneumonia (VAP). Study design: Prospective randomized study. Patients and methods: Adults patients ventilated for more than 48 hours in the intensive care unit (ICU) with a clinical diagnosis of VAP documented by positive quantitative cultures of tracheal aspiration were included in this study. All included patients were randomized in two groups. Ten-day group: 10 days antibiotic therapy, and 7-day group: 7 days antibiotic therapy. Primary judgment criteria were 14- and 28-day mortality, the number of days without antibiotics. Secondary judgments criteria were rate of recurrent pulmonary infection, the evolution of the clinical pulmonary infection scores (CPIS), the length of ICU stay and the length of mechanical ventilation. Results: Thirty patients were included in this study (16 in the 10-day group and 14 in the 7-day group). The demographic and clinical characteristics of the groups assigned to receive antibiotic therapy for 7 or 10 days were generally similar. The 14-day and 28-day mortality rate following VAP onset were 31.2 and 37.5% in the 10-day group and 7.1 and 35.7% in the 7-day group. The difference was not significant. The number of day without antibiotics and without mechanical ventilation turned out: 1.75 and 2.06 days versus 4.14 and 3.43 days in the 10-day group and 7-day group respectively, the recurrent rate of pulmonary infection (12.5% versus 14.3%, p = 0.6), the length of stay in the ICU (27.7 days versus 26.0 days, p = 0.8) and the evolution of the CPIS were no different in the two groups. Conclusion: In patients with microbiologically confirmed VAP who received appropriate empirical antibiotic therapy, a 7-day antibiotic regimen was as efficient clinically and microbiologically as a 10-day antibiotic regimen with a reduction of antibiotic use. © 2008 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Fekih-Hassen, Mohamed
Tunisia, Tunis
Chu Taher Sfar Mahdia
Ayed, Saïd Ben
Tunisia, Tunis
Chu Taher Sfar Mahdia
Ben Sik-Ali, Habiba
Tunisia, Tunis
Chu Taher Sfar Mahdia
Gharbi, Rim
Tunisia, Tunis
Chu Taher Sfar Mahdia
Marghli, Soudani
Tunisia, Tunis
Chu Taher Sfar Mahdia
ElAtrous, Souheil
Tunisia, Tunis
Chu Taher Sfar Mahdia
Statistics
Citations: 24
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1016/j.annfar.2008.10.021
ISSN:
07507658
Study Design
Cohort Study
Study Approach
Quantitative