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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
An open randomized comparative study of intramuscular artemether and intravenous quinine in cerebral malaria in children
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 87, No. 5, Year 1993
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Description
We have compared a multi-dose intramuscular regime of artemether against the standard intravenous quinine treatment for cerebral malaria in an open randomized study. Parasite clearance time, fever clearance time, and time to recover from coma were similar in the 2 groups of patients. Although the mortality rate was lower in the artemether group, the difference was not statistically significant. There was no toxic reaction of note in the artemether group. We therefore conclude that, because of its ease of administration and good toxicity profile, artemether is more suited for use in the rural regions of malaria endemic areas, where monitoring facilities may be minimal, compared to quinine which is potentially toxic. © 1993 Oxford University Press.
Authors & Co-Authors
Walker, Oladapo
Nigeria, Ibadan
University of Ibadan
Salako, Lateef A.
Nigeria, Ibadan
University of Ibadan
Sowunmi, Akintunde
Nigeria, Ibadan
University of Ibadan
Omokhodion, Samuel Ilenre
Nigeria, Ibadan
University of Ibadan
Statistics
Citations: 40
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/0035-9203(93)90092-5
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health