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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Susceptibility of Mycobacterium ulcerans to a combination of amikacin/rifampicin
International Journal of Antimicrobial Agents, Volume 22, No. 6, Year 2003
Notification
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Description
The effectiveness of rifampicin (RIF), amikacin (AMK) and their combination were estimated in the treatment of mice experimentally infected by Mycobacterium ulcerans and the risk of relapse after the treatment was evaluated. After 7 weeks of treatment with RIF or with the combination of AMK/RIF and 8 weeks with AMK alone, no viable bacilli were found in the infected tissues and these remained uninfected during the following 6 months. Among the mice treated with AMK alone, three mice relapsed, but the minimal inhibitory concentration of AMK for these isolates remained unchanged. With RIF alone, two mice relapsed and the minimal inhibitory concentration of these isolated strains was higher. However, with all the mice treated with both RIF and AMK, no relapse was observed. © 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Authors & Co-Authors
Marsollier, Laurent
France, Angers
Chu Angers
Prévot, G. I.
French Guiana, Cayenne
Institut Pasteur de la Guyane
Honoré, Nadine
France, Paris
Institut Pasteur, Paris
Legras, Pierre
France, Angers
Chu Angers
Manceau, Anne Lise
France, Angers
Chu Angers
Payan, Christopher
France, Angers
Chu Angers
Kouakou, Henri
Cote D'ivoire, Adzope
Institut Raoul-follereau de Cote-d'ivoire a Adzope
Carbonnelle, Bernard
France, Angers
Chu Angers
Statistics
Citations: 38
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/S0924-8579(03)00240-1
ISSN:
09248579
Research Areas
Cancer