Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV-specific IL-10-positive CD8
+
T cells are increased in advanced disease and are associated with decreased HIV-specific cytolysis
Journal of Immunology, Volume 176, No. 2, Year 2006
Notification
URL copied to clipboard!
Description
IL-10-producing T cells have been shown to inhibit Ag-specific CD8 + T cell responses, and may play a role in the immune dysregulation observed in HIV-1 infection. We characterized the Gag-specific IL-10 responses by CD8+ T cells in HIV-1-positive volunteers from Uganda. HIV-specific IL-10 responses were detected in 32 of 61 (52.4%) antiretroviral naive and 2 of 15 (13.3%) volunteers with a complete virologic response on antiretroviral therapy (< 400 copies/ml). The frequency of HIV-specific IL-10-positive cells was significantly higher in volunteers with advanced disease (CD4+ T cell count <200 cells/mm3; p = 0.0004), and correlated positively with plasma HIV RNA (r = 0.43, p = 0.0004). Interestingly, the frequency of Gag-specific CD107a/b-, but not IFN-γ-, positive cells was significantly lower in individuals with detectable IL-10-positive CD8+ T cells (p = 0.004). Gag-specific IL-10-positive CD8+ T cells demonstrated a pattern of surface memory marker expression that is distinct compared with CD107a/b- and IFN-γ-positive CD8+ T cell populations (p < 0.0001). Our study describes a distinct population of IL-10-positive CD8+ T cells that may play a role in HIV-associated immune dysfunction. Copyright © 2006 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Elrefaei, Mohamed
United States, Sacramento
California Department of Health Services
United States, Berkeley
Viral Rickettsial Disease Laboratory
Barugahare, Banson John
Uganda, Kampala
Joint Clinical Research Center Uganda
Ssali, Francis N.
Uganda, Kampala
Joint Clinical Research Center Uganda
Mugyenyi, Peter N.
Uganda, Kampala
Joint Clinical Research Center Uganda
Cao, Huyen L.
United States, Sacramento
California Department of Health Services
Statistics
Citations: 46
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.4049/jimmunol.176.2.1274
ISSN:
00221767
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Uganda