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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The results of treatment of children with metastatic Wilms tumours (WT) in an African setting: Do liver metastases have a negative impact on survival?
Pediatric Blood and Cancer, Volume 59, No. 2, Year 2012
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Description
Background: From Africa, where socio-economic circumstances differ from the developed world, there are no data regarding the influence of liver metastases on survival of children with Wilms tumour. Procedure: One hundred fifty new patients with WT were seen between 2002 and 2010, 45 (30%) had metastases at diagnosis. Seven patients had bilateral disease with additional visceral metastases. Nine patients who developed liver metastases during treatment were excluded. The site of metastases and the results of pretreatment biopsies were retrieved. Neo-adjuvant chemotherapy was combined with nutritional resuscitation, and aggressive supportive care. Post-operative treatment was determined by stage and histology. Results: Liver metastases were present in 19 (42%) patients but were the sole metastatic site in only 4 (9%). Overall survival at 5 years was 58.5%. Event Free Survival was 54%. Thirty-three (73%) had favourable histology, nine unfavourable and undetermined in three. No influence of histology on outcome was evident. Three patients had resection of persistent liver metastases. The pattern of metastatic disease had no influence on outcome. Despite aggressive supportive care two patients (4%) died within a week of presentation. Two patients died of chemotoxicity and two of complications following biopsy. Eight patients (17%) were lost to follow-up of whom five were on palliative treatment only. Conclusions: In Africa liver metastases do not appear to worsen the prognosis of children with Stage IV WT. Despite the poor socio-economic circumstances survival is comparable to other countries. © 2012 Wiley Periodicals, Inc..
Authors & Co-Authors
Aronson, Daniël C.
South Africa, Durban
Inkosi Albert Luthuli Central Hospital
Maharaj, Ashwini G.
South Africa, Durban
Inkosi Albert Luthuli Central Hospital
Sheik-Gafoor, Mohamed Hoosen
South Africa, Durban
Inkosi Albert Luthuli Central Hospital
Hadley, Grenville Peter
South Africa, Durban
Inkosi Albert Luthuli Central Hospital
Statistics
Citations: 9
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1002/pbc.24080
ISSN:
15455009
e-ISSN:
15455017
Research Areas
Cancer
Maternal And Child Health
Study Design
Cohort Study