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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased risk of HIV acquisition among kenyan men with human papillomavirus infection
Journal of Infectious Diseases, Volume 201, No. 11, Year 2010
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Description
Background. Few data on the effect of human papillomavirus (HPV) infection on human immunodeficiency virus (HIV) acquisition are available. Methods. HIV-seronegative, sexually active, 18-24-year-old Kenyan men participating in a randomized trial of male circumcision provided exfoliated penile cells from 2 anatomical sites (glans/coronal sulcus and shaft) at baseline. The GP5+/6+ polymerase chain reaction assay ascertained a wide range of HPV DNA types at the baseline visit. The risk of HIV infection was estimated using Kaplan-Meier methods and hazard ratios from proportional hazards models. Results. Of 2168 uncircumcised men with baseline HPV data, 1089 (50%) were positive for HPV DNA. The cumulative incidence of HIV infection by 42 months was 5.8% (95% confidence interval [CI], 3.6% - 7.9%) among men with HPV-positive glans/coronal sulcus specimens, versus 3.7% [95% CI, 1.8% - 5.6%] among men with HPVnegative glans/coronal sulcus specimens (P = .01). Controlling for subsequent circumcision status, baseline herpes simplex virus type 2 serostatus, and sexual and sociodemographic risk factors, the hazard ratio for HIV infection among men with HPV-positive glans/coronal sulcus specimens was 1.8 (95% CI, 1.1-2.9), compared with men with HPV-negative glans/coronal sulcus specimens. Conclusion. The results suggest an independent increased risk of HIV seroconversion among HPV-positive men. If this finding is confirmed in other studies, HPV prevention could be another tool for HIV prevention. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Smith, Jennifer Susan
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Moses, Stephen
Canada, Winnipeg
University of Manitoba
Hudgens, Michael G.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Parker, Corette Breeden
Australia, Research Triangle Park
Research Triangle Park
Agot, Kawango E.
Kenya, Nairobi
University of Nairobi
Kenya
Manitoba Unim Project
MacLean, Ian W.
Canada, Winnipeg
University of Manitoba
Ndinya-Achola, Jeckoniah O.
Kenya, Nairobi
University of Nairobi
Snijders, Peter Jf
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Meijer, Chris J.L.M.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Bailey, Robert C.
United States, Chicago
University of Illinois at Chicago
Statistics
Citations: 85
Authors: 10
Affiliations: 7
Identifiers
Doi:
10.1086/652408
ISSN:
00221899
Research Areas
Cancer
Environmental
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Male