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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Brominated furanones inhibit biofilm formation by Salmonella enterica serovar Typhimurium
Applied and Environmental Microbiology, Volume 74, No. 21, Year 2008
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Description
Salmonella enterica serovar Typhimurium is a main cause of bacterial food-borne diseases. As Salmonella can form biofilms in which it is better protected against antimicrobial agents on a wide diversity of surfaces, it is of interest to explore ways to inhibit biofilm formation. Brominated furanones, originally extracted from the marine alga Delisea pulchra, are known to interfere with biofilm formation in several pathogens. In this study, we have synthesized a small focused library of brominated furanones and tested their activity against S. enterica serovar Typhimurium biofilm formation. We show that several furanones inhibit Salmonella biofilm formation at non-growth-inhibiting concentrations. The most interesting compounds are (Z)-4-bromo-5- (bromomethylene)-3-alkyl-2(5H)-furanones with chain lengths of two to six carbon atoms. A microarray study was performed to analyze the gene expression profiles of Salmonella in the presence of (Z)-4-bromo-5-(bromomethylene)-3-ethyl-2(5H)- furanone. The induced genes include genes that are involved in metabolism, stress response, and drug sensitivity. Most of the repressed genes are involved in metabolism, the type III secretion system, and flagellar biosynthesis. Follow-up experiments confirmed that this furanone interferes with the synthesis of flagella by Salmonella. No evidence was found that furanones act on the currently known quorumsensing systems in Salmonella. Interestingly, pretreatment with furanones rendered Salmonella biofilms more susceptible to antibiotic treatment. Conclusively, this work demonstrates that particular brominated furanones have potential in the prevention of biofilm formation by Salmonella serovar Typhimurium. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Steenackers, Hans P.L.
Belgium, Leuven
Ku Leuven
Marchal, Kathleen
Belgium, Leuven
Ku Leuven
Vanderleyden, Jos X.
Belgium, Leuven
Ku Leuven
de Vos, Dirk E.
Belgium, Leuven
Ku Leuven
De Keersmaecker, Sigrid C.J.
Belgium, Leuven
Ku Leuven
Statistics
Citations: 205
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1128/AEM.01262-08
ISSN:
00992240
Research Areas
Environmental
Food Security
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study