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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis in middle-aged adults
Nephrology Dialysis Transplantation, Volume 22, No. 4, Year 2007
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Description
Background: Cystatin C, a marker of renal function, has been shown to be an independent predictor of cardiovascular disease (CVD) in older adults, but few data are available in middle-aged adults. Moreover, no study has compared cystatin C and microalbuminuria as risk factors for CVD outcomes in middle-aged adults, and it is not known whether cystatin C is related to an early stage of atherosclerosis. Methods: We evaluated the relationships between serum creatinine, estimated glomerular filtration rate (GFR), serum cystatin C (all divided into tertiles), microalbuminuria and carotid atherosclerosis in a population-based random sample of 523 adults aged 35-64 years from the Seychelles (Indian Ocean). GFR was estimated using the modification of diet in renal disease (MDRD) equation. Intima-media thickness (IMT) was assessed by B-mode ultrasound. Results: The mean age of the study sample was 52 years, and 55% were women. Carotid IMT was higher in participants with microalbuminuria (802 vs 732 μm, P < 0.001) and was inversely associated with GFR tertiles (from 728 to 809 μm, P for trend = 0.002). IMT was not associated with cystatin C or creatinine (P for trend = 0.10 and 0.16, respectively). In multivariate analyses adjusted for cardiovascular risk factors, the association between microalbuminuria and IMT remained (P = 0.047), while the association between GFR and IMT disappeared (P for trend = 0.33). Conclusions: Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis beyond traditional cardiovascular risk factors among middle-aged adults. Cystatin C does not have a stronger relationship with carotid atherosclerosis in middle-aged adults than creatinine. © 2007 Oxford University Press.
Authors & Co-Authors
Rodondi, Nicolas
Switzerland, Lausanne
Université de Lausanne Unil
Switzerland, Lausanne
Institut Universitaire de Médecine Sociale et Préventive Lausanne
Yerly, Patrick
Switzerland, Lausanne
Université de Lausanne Unil
Gabriel, Anne
Seychelles, Mahe
Ministry of Health Seychelles
Riesen, Walter F.
Switzerland, Olten
Kantonsspital Olten
Burnier, Michel
Switzerland, Lausanne
Université de Lausanne Unil
Paccaud, Fred Michel
Switzerland, Lausanne
Institut Universitaire de Médecine Sociale et Préventive Lausanne
Bovet, Pascal
Switzerland, Lausanne
Institut Universitaire de Médecine Sociale et Préventive Lausanne
Seychelles, Mahe
Ministry of Health Seychelles
Statistics
Citations: 7
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1093/ndt/gfl733
ISSN:
09310509
e-ISSN:
14602385
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Seychelles
Participants Gender
Female