Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impact of HIV on host-virus interactions during early hepatitis C virus infection
Journal of Infectious Diseases, Volume 197, No. 11, Year 2008
Notification
URL copied to clipboard!
Description
Background. Human immunodeficiency virus (HIV) may influence the outcome and natural history of hepatitis C virus (HCV) infection through an impact on acute HCV-specific T cell responses. Methods. Fifty-five HIV-positive males with acute HCV infection were identified; monoinfected individuals (n = 8) were used for peripheral blood mononuclear cell comparison. In 14 coinfected and 8 HCV-monoinfected patients, HCV-specific T cell responses against a range of HCV antigens were assessed using interferon (IFN)-γ enzyme-linked immunospot (ELISpot) and proliferation assays. E1/E2 region genetic diversity and the selection pressure on the virus were measured in 8 coinfected patients by use of cloned sequences over time. Results. HCV persisted in 52 (95%) coinfected individuals. HCV/HIV coinfection significantly reduced IFN-γ ELISpot responses versus those in HCV-monoinfected individuals, especially against nonstructural proteins (1/10 vs. 5/8; P = .008). In coinfected patients, increased HCV genetic diversity was observed between the first and subsequent time points, with no evidence for positive selection in the E1/E2 region sequenced. Conclusion. HIV coinfection is associated with increased rates of HCV persistence and a lack of critical CD4 T cell responses, with no evidence of immune selection pressure during early HCV infection. Loss of key cellular immune responses against HCV during acute disease may contribute to the failure of early host control of HCV in HCV/HIV-coinfected patients. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Fabris, Paolo
United Kingdom, Oxford
University of Oxford
Italy, Vicenza
Ospedale San Bortolo
Brown, David J.C.
United Kingdom, London
Ucl Medical School
Pybus, Oliver George
United Kingdom, Oxford
University of Oxford
Sabin, Caroline Anne
United Kingdom, London
Ucl Medical School
Bhagani, Sanjay R.
United Kingdom, London
Ucl Medical School
Emery, Vince
United Kingdom, London
Ucl Medical School
Dusheiko, Geoffrey M.
United Kingdom, London
Ucl Medical School
Klenerman, Paul
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Statistics
Citations: 91
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1086/587843
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases