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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm
Journal of viral hepatitis, Volume 21, Year 2014
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Description
The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing. © 2014 John Wiley & Sons Ltd.
Authors & Co-Authors
Razavi, Homie A.
United States, Louisville
Center for Disease Analysis
Waked, I. A.
United States, Louisville
Center for Disease Analysis
Sarrazin, Christoph M.
United States, Louisville
Center for Disease Analysis
Idilman, Ramazan
United States, Louisville
Center for Disease Analysis
Calinas, Filipe
United States, Louisville
Center for Disease Analysis
Vogel, Wolfgang
United States, Louisville
Center for Disease Analysis
Mendes-Corrěa, Maria Cássia Jacintho
United States, Louisville
Center for Disease Analysis
Heźode, Christophe
United States, Louisville
Center for Disease Analysis
Akarca, Ulus Salih
United States, Louisville
Center for Disease Analysis
Aleman, Soo
United States, Louisville
Center for Disease Analysis
Berg, Thomas
United States, Louisville
Center for Disease Analysis
Bihl, Florian K.
United States, Louisville
Center for Disease Analysis
Bilodeau, Marc
United States, Louisville
Center for Disease Analysis
Blasco, Antonio Javier
United States, Louisville
Center for Disease Analysis
Brandão-Mello, Carlos Eduardo
United States, Louisville
Center for Disease Analysis
Bruggmann, Philip
United States, Louisville
Center for Disease Analysis
Butí, María Asunción
United States, Louisville
Center for Disease Analysis
Calleja-Panero, José Luis
United States, Louisville
Center for Disease Analysis
Cheinquer, Hugo
United States, Louisville
Center for Disease Analysis
Christensen, Peer Brehm
United States, Louisville
Center for Disease Analysis
Clausen, Mette Rye
United States, Louisville
Center for Disease Analysis
Cramp, M. E.
United States, Louisville
Center for Disease Analysis
Dore, Gregory J.
United States, Louisville
Center for Disease Analysis
Doss, Wahid H.
United States, Louisville
Center for Disease Analysis
Duberg, Ann Sofi
United States, Louisville
Center for Disease Analysis
El-Sayed, Manal Hamdy
United States, Louisville
Center for Disease Analysis
Ergor, Gul
United States, Louisville
Center for Disease Analysis
Esmat, Gamal
United States, Louisville
Center for Disease Analysis
Falconer, Karolin
United States, Louisville
Center for Disease Analysis
Ferraz, Maria Lucia Gomes Lúcia Gomes
United States, Louisville
Center for Disease Analysis
Ferreira, Paulo Roberto Abrão
United States, Louisville
Center for Disease Analysis
Fraňková, Soňa
United States, Louisville
Center for Disease Analysis
García-Samaniego, Javier
United States, Louisville
Center for Disease Analysis
Gerstoft, Jan
United States, Louisville
Center for Disease Analysis
Gonçales, Fernando Lopes
United States, Louisville
Center for Disease Analysis
Gower, Erin E.
United States, Louisville
Center for Disease Analysis
Gschwantler, Michael
United States, Louisville
Center for Disease Analysis
Pessoa, Mário Guimarães
United States, Louisville
Center for Disease Analysis
Blach, Sarah
United States, Louisville
Center for Disease Analysis
Hofer, Harald O.
United States, Louisville
Center for Disease Analysis
Husa, Petr
United States, Louisville
Center for Disease Analysis
Kåberg, Martin
United States, Louisville
Center for Disease Analysis
Kautz, Achim
United States, Louisville
Center for Disease Analysis
Kaymakoĝlu, Sabahattin
United States, Louisville
Center for Disease Analysis
Krajden, Mel
United States, Louisville
Center for Disease Analysis
Krarup, Henrik B.
United States, Louisville
Center for Disease Analysis
Laleman, Wim J.
United States, Louisville
Center for Disease Analysis
Lavanchy, Daniel
United States, Louisville
Center for Disease Analysis
Marinho, Rui Tato
United States, Louisville
Center for Disease Analysis
Marotta, Paul J.
United States, Louisville
Center for Disease Analysis
Moreno, Christophe
United States, Louisville
Center for Disease Analysis
Murphy, Kimberly
United States, Louisville
Center for Disease Analysis
Negro, Francesco
United States, Louisville
Center for Disease Analysis
Örmeci, Necati
United States, Louisville
Center for Disease Analysis
Peltekian, Kevork Minas
United States, Louisville
Center for Disease Analysis
Ramji, Alnoor S.
United States, Louisville
Center for Disease Analysis
Roberts, Stuart Keith
United States, Louisville
Center for Disease Analysis
Roudot-Thoraval, Françoise
United States, Louisville
Center for Disease Analysis
Semela, David
United States, Louisville
Center for Disease Analysis
Shiha, Gamal Elsayed
United States, Louisville
Center for Disease Analysis
Sievert, William
United States, Louisville
Center for Disease Analysis
Star̈kel, Peter
United States, Louisville
Center for Disease Analysis
Stauber, Rudolf E.
United States, Louisville
Center for Disease Analysis
Thompson, Alex Cargill
United States, Louisville
Center for Disease Analysis
Van-Damme, Pierre A.
United States, Louisville
Center for Disease Analysis
Wedemeyer, Heiner
United States, Louisville
Center for Disease Analysis
Weis, Nina M.
United States, Louisville
Center for Disease Analysis
Wiegand, Johannes
United States, Louisville
Center for Disease Analysis
Yosry, Ayman
United States, Louisville
Center for Disease Analysis
Cornberg, Markus
United States, Louisville
Center for Disease Analysis
Mul̈lhaupt, Beat
United States, Louisville
Center for Disease Analysis
Estes, Chris R.
United States, Louisville
Center for Disease Analysis
Statistics
Citations: 475
Authors: 72
Affiliations: 1
Identifiers
Doi:
10.1111/jvh.12248
ISSN:
13652893
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study