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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues
Vaccine, Volume 28, No. 1, Year 2009
Notification
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Description
The BM86 antigen, originally identified in Rhipicephalus (Boophilus) microplus, is the basis of the only commercialized anti-tick vaccine. The long-term goal of our study is to improve BM86 based vaccines by induction of high levels of tick gut binding antibodies that are also cross-reactive with a range of BM86 homologues expressed in other important tick species. Here we have used a BD86 derived synthetic peptide, BD86-3, to raise a series of mouse monoclonal antibodies. One of these mAbs, named 12.1, recognized BM86 homologues in immuno-histochemical analyses in four out of five tick species including R. (B.) microplus, Rhipicephalus (Boophilus) decoloratus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus. Our results indicate that broadly cross-reactive tick gut binding antibodies can be induced after immunization with a synthetic peptide derived from the protein BD86. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Kopp, Nadja
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Díaz, Diana P.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Amacker, Mario
Switzerland, Bern
Pevion Biotech Ltd
Odongo, David Otieno
Kenya, Nairobi
International Livestock Research Institute Nairobi
Kenya, Nairobi
University of Nairobi
Beier, Konstantin
Switzerland, Basel
Anatomie Der Universität Basel
Nitsch, Cordula
Switzerland, Basel
Anatomie Der Universität Basel
Bishop, Richard Peter
Kenya, Nairobi
International Livestock Research Institute Nairobi
Daubenberger, Claudia Andrea
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Statistics
Citations: 8
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/j.vaccine.2009.09.085
ISSN:
0264410X
Research Areas
Maternal And Child Health