Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations
Psychiatric Genetics, Volume 20, No. 6, Year 2010
Notification
URL copied to clipboard!
Description
Objective: The Disrupted-in-Schizophrenia-1 (DISC1) gene is a promising genetic risk factor for major mental illnesses, especially schizophrenia. Several variants encompassing the DISC1 gene have been associated with schizophrenia and specific clinical features. Negative Results were nevertheless observed, stratification biases, heterogeneity of the analyzed samples and low statistical power being potentially involved. Methods: We analyzed four single nucleotide polymorphisms (SNPs), including three non-synonymous SNPs, of DISC1 in two independent samples of trios, from France and Algeria, using family-based association tests to elude statistical limits. Results: In 114 French schizophrenia trios, the C allele of non-synonymous rs6675281/Leu607Phe/C1872T was significantly over-transmitted [odds ratio (OR)=2.3, 95% confidence interval (CI)=1.1-4.4]. This same SNP was also more frequently transmitted in the 100 Algerian schizophrenia trios (OR=2.6, 95% CI=0.9-7.3). In the combined 214 trios, a significant over-transmission of the C allele of rs6675281 to the affected probands was observed (P=0.002), even after correction for multiple testing (Pcorrected=0.01 OR=2.4 and 95% CI=1.3-4.2). Assessing if a dimension of schizophrenia could be more specifically involved, we found that patients with the C allele had a significantly higher Scale for the Assessment of Negative Symptoms total score (P=0.0002). Conclusion: The analysis adds convergent evidence in favor of a significant role of the DISC1 gene as a risk factor for schizophrenia, as present in two different samples, in family trios rather than with a case-control approach, and even when multiple tests are controlled for. We could further potentially attribute this effect to the negative dimension of schizophrenia. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Authors & Co-Authors
Lepagnol-Bestel, Aude Marie
France, Paris
Inserm
Dubertret, Caroline
France, Paris
Inserm
France, Colombes
Hopital Louis-mourier
Benmessaoud, Dalila
Algeria, Algiers
Etablissement Hospitalier Spécialisé Psychiatrique M. Boucebci. Cheraga
Simonneau, Michel
France, Paris
Inserm
Adès, Jean
France, Paris
Inserm
France, Colombes
Hopital Louis-mourier
Kacha, Farid
Algeria, Algiers
Etablissement Hospitalier Spécialisé Psychiatrique M. Boucebci. Cheraga
Hamdani, Nora
France, Creteil
Hôpital Albert Chenevier Ap-hp Paris
Gorwood, Philip A.P.M.
France, Paris
Inserm
France, Paris
Centre Hospitalier Sainte-anne
Ramoz, Nicolas
France, Paris
Inserm
Statistics
Citations: 22
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1097/YPG.0b013e32833aa5c4
ISSN:
09558829
Research Areas
Genetics And Genomics
Mental Health
Study Design
Case-Control Study
Study Locations
Algeria