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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The Spread of Multiply Resistant Streptococcus pneumoniae at a Day Care Center in Ohio
Journal of Infectious Diseases, Volume 166, No. 6, Year 1992
Notification
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Description
Streptococcus pneumoniae, type 23F, resistant to penicillin (MIC, 2 μg/mL) and multiple other antimicrobic agents, was isolated from middle ear fluid of a child with otitis media attending a day care center in Ohio. To determine the extent of spread of this strain, nasopharyngeal culture surveys were done, and 52 carriers were identified among 250 children attending the index day care center. No carriers were found among 121 children at two other day care centers in the same urban area. Use of prophylactic doses of antibiotics (P <.001) and frequent use of antibiotics (P <.001) were risk factors for nasopharyngeal carriage. Carriers were more likely to have had frequent otitis media episodes (P <.02) and otitis media not responsive to antimicrobial therapy (P <.001). Strategies to limit the spread of highly resistant pneumococcal strains should include encouraging judicious use of antimicrobic agents and reevaluating indications for prophylactic use of antimicrobic agents. © 1992 the University of Chicago.
Authors & Co-Authors
Reichler, Mary R.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
United States, Cleveland
Case Western Reserve University
Breiman, Robert F.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
United States, Cleveland
Case Western Reserve University
McDougal, Linda Kirven
United States, Atlanta
National Center for Immunization and Respiratory Diseases
United States, Cleveland
Case Western Reserve University
Facklam, Richard R.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
United States, Cleveland
Case Western Reserve University
Jacobs, Michael R.
United States, Atlanta
National Center for Immunization and Respiratory Diseases
United States, Cleveland
Case Western Reserve University
Statistics
Citations: 398
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1093/infdis/166.6.1346
ISSN:
00221899
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study