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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Multiclonal asymptomatic Plasmodium falciparum infections predict a reduced risk of malaria disease in a Tanzanian population
Microbes and Infection, Volume 9, No. 1, Year 2007
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Description
Protective immunity to malaria is acquired after repeated exposure to the polymorphic Plasmodium falciparum parasite. Whether the number of concurrent antigenically diverse clones in asymptomatic infections predicts the risk of subsequent clinical malaria needs further understanding. We assessed the diversity of P. falciparum infections by merozoite surface protein 2 genotyping in a longitudinal population based study in Tanzania. The number of clones was highest in children 6-10 years and in individuals with long time to previous anti-malarial treatment. Individual exposure, analysed by circumsporozoite protein antibody levels, was associated with parasite prevalence but not with the number of clones. The risk of subsequent clinical malaria in children free of acute disease or recent treatment was, compared to one clone, reduced in individuals with multiclonal infections or without detectable parasites, with the lowest hazard ratio 0.28 (95% confidence interval 0.10-0.78 Cox regression) for 2-3 clones. The number of clones was not associated with haemoglobin levels. A reduced risk of malaria in asymptomatic individuals with multiclonal persistent P. falciparum infections suggests that controlled maintenance of diverse infections is important for clinical protection in continuously exposed individuals, and needs to be considered in the design and evaluation of new malaria control strategies. © 2006 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Bereczky, Sándor
Sweden, Stockholm
Karolinska Institutet
Liljander, Anne
Sweden, Stockholm
Karolinska Institutet
Rooth, Ingegerd B.
Tanzania, Tanga
National Institute for Medical Research Tanga
Faraja, Lea
Tanzania, Tanga
National Institute for Medical Research Tanga
Granath, Fredrik N.
Sweden, Stockholm
Karolinska Institutet
Montgomery, Scott M.
Sweden, Stockholm
Karolinska Institutet
Sweden, Orebro
Universitetssjukhuset Örebro
Färnert, Anna
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 81
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.micinf.2006.10.014
ISSN:
12864579
e-ISSN:
1769714X
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Tanzania