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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys
Acta Paediatrica, International Journal of Paediatrics, Volume 98, No. 9, Year 2009
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Description
Aim: We investigate the effects of a 2-month weight-loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys. Methods: Twenty-one obese adolescent boys (BMI = 30.8 ± 3.2 kg/m 2) completed the weight-loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipoxmax) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention. Results: Following the weight-loss programme, adolescents of the RE group showed an improvement of their body composition (p < 0.01), an increase in plasma adiponectin (+73.7%, p < 0.01) and a decrease in plasma leptin (-38.8%, p < 0.01) leading to an increase in adiponectine/leptin ratio (ALR, +144.4%, p < 0.01) higher than the R or E groups. E and RE groups only showed a similar significant increase in plasma resistin (p < 0.05) and a significant improvement of lipid oxidation rate at Lipoxmax (p < 0.01 and p < 0.001). In addition, in RE group, ALR is correlated with waist/hip and waist/height ratios, resistin level, homoeostasis mode assessment (HOMA-IR) index and Lipoxmax. Conclusion: In obese adolescents boys, moderate exercise training completed at Lipoxmax and combined with energy restriction improves their ability to oxidize lipids, which is associated with a normalization of their adiponectin, leptin and resistin levels resulting in an improved insulin sensitivity, as attested by a higher ALR and a lower HOMA-IR. © 2009 Foundation Acta Pædiatrica.
Authors & Co-Authors
Elloumi, Mohamed
France, Clermont-ferrand
Université Clermont Auvergne
Tunisia, Sousse
Faculty of Medicine Sousse
Ben Ounis, Omar
Tunisia, Sousse
Faculty of Medicine Sousse
Makni, Emna
Tunisia, Sousse
Faculty of Medicine Sousse
Van-Praagh, Emmanuel
France, Clermont-ferrand
Université Clermont Auvergne
Tabka, Zouhaïr
Tunisia, Sousse
Faculty of Medicine Sousse
Lac, Gérard
France, Clermont-ferrand
Université Clermont Auvergne
Statistics
Citations: 112
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1111/j.1651-2227.2009.01365.x
ISSN:
08035253
e-ISSN:
16512227
Study Design
Randomised Control Trial
Participants Gender
Male