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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
Nature, Volume 595, No. 7865, Year 2021
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Description
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure1–4, but little is known about its pathophysiology. Here we generated single-cell atlases of 24 lung, 16 kidney, 16 liver and 19 heart autopsy tissue samples and spatial atlases of 14 lung samples from donors who died of COVID-19. Integrated computational analysis uncovered substantial remodelling in the lung epithelial, immune and stromal compartments, with evidence of multiple paths of failed tissue regeneration, including defective alveolar type 2 differentiation and expansion of fibroblasts and putative TP63+ intrapulmonary basal-like progenitor cells. Viral RNAs were enriched in mononuclear phagocytic and endothelial lung cells, which induced specific host programs. Spatial analysis in lung distinguished inflammatory host responses in lung regions with and without viral RNA. Analysis of the other tissue atlases showed transcriptional alterations in multiple cell types in heart tissue from donors with COVID-19, and mapped cell types and genes implicated with disease severity based on COVID-19 genome-wide association studies. Our foundational dataset elucidates the biological effect of severe SARS-CoV-2 infection across the body, a key step towards new treatments. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
Authors & Co-Authors
Ziegler, Carly G.K.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Harvard University
Heimberg, Graham S.
United States, Cambridge
Massachusetts Institute of Technology
Subramanian, Ayshwarya
United States, Cambridge
Massachusetts Institute of Technology
Montoro, Daniel T.
United States, Cambridge
Massachusetts Institute of Technology
Jagadeesh, Karthik A.
United States, Cambridge
Massachusetts Institute of Technology
Slyper, Michal
United States, Cambridge
Massachusetts Institute of Technology
Ganna, Andrea
Finland, Helsinki
Helsingin Yliopisto
United States, Boston
Massachusetts General Hospital
Gomez, James E.
United States, Cambridge
Massachusetts Institute of Technology
Normandin, Erica
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
Tsai, Linus T.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Beth Israel Deaconess Medical Center
Siddle, Katherine J.
United States, Cambridge
Massachusetts Institute of Technology
United States, Cambridge
Harvard University
Amir-Zilberstein, Liat
United States, Cambridge
Massachusetts Institute of Technology
Atri, Deepak S.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Brigham and Women's Hospital
Gould, Joshua Z.
United States, Cambridge
Massachusetts Institute of Technology
Harvey, Tyler
United States, Cambridge
Massachusetts Institute of Technology
Hecht, Jonathan L.
United States, Boston
Harvard Medical School
United States, Boston
Beth Israel Deaconess Medical Center
Leney-Greene, Michael A.
United States, Cambridge
Massachusetts Institute of Technology
Muus, Christoph
United States, Cambridge
Massachusetts Institute of Technology
United States, Cambridge
Harvard University
Waghray, Avinash
United States, Cambridge
Harvard Stem Cell Institute
United States, Boston
Massachusetts General Hospital
Cosimi, Lisa A.
United States, Boston
Brigham and Women's Hospital
Gupta, Rajat M.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Brigham and Women's Hospital
Hacohen, Nir
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Hide, Winston A.
United States, Boston
Harvard Medical School
United States, Boston
Beth Israel Deaconess Medical Center
Price, Alkes L.
United States, Cambridge
Harvard University
Rajagopal, Jay
United States, Boston
Massachusetts General Hospital
Tata, Purushothama Rao
United States, Durham
Duke University School of Medicine
Riedel, Stefan
United States, Boston
Harvard Medical School
United States, Boston
Beth Israel Deaconess Medical Center
Szabo, Gyongyi
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Beth Israel Deaconess Medical Center
Ellinor, Patrick T.
United States, Cambridge
Massachusetts Institute of Technology
Hung, Deborah T.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Sabeti., Pardis C.
United States, Cambridge
Massachusetts Institute of Technology
United States, Cambridge
Harvard University
United States, Chevy Chase
Howard Hughes Medical Institute
United States, Boston
Massachusetts Consortium on Pathogen Readiness
Vlachos, Ioannis S.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Beth Israel Deaconess Medical Center
Ashenberg, Orr
United States, Cambridge
Massachusetts Institute of Technology
Li, Bo
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Shalek, Alex K.
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Harvard University
United States, Cambridge
Harvard Stem Cell Institute
Villani, Alexandra Chloé
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Rozenblatt-Rosen, Orit
United States, Cambridge
Massachusetts Institute of Technology
United States, San Francisco
Genentech, Inc
Regev, Aviv
United States, Cambridge
Massachusetts Institute of Technology
United States, Chevy Chase
Howard Hughes Medical Institute
United States, San Francisco
Genentech, Inc
Statistics
Citations: 365
Authors: 38
Affiliations: 18
Identifiers
Doi:
10.1038/s41586-021-03570-8
ISSN:
00280836
Research Areas
Covid