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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasma aldosterone is independently associated with the metabolic syndrome
Hypertension, Volume 48, No. 2, Year 2006
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Description
The aim of this study was to analyze the associations of plasma aldosterone and plasma renin activity with the metabolic syndrome and each of its components. We analyzed data from a family based study in the Seychelles made up of 356 participants (160 men and 196 women) from 69 families of African descent. In multivariable models, plasma aldosterone was associated positively (P<0.05) with blood pressure in older individuals (interaction with age, P<0.05) and with waist circumference in men (interaction with sex, P<0.05) and negatively with high-density lipoprotein cholesterol, in particular in individuals with elevated urinary potassium excretion (interaction with urinary potassium, P<0.05); plasma renin activity was significantly associated with triglycerides and fasting blood glucose. Plasma aldosterone, but not plasma renin activity, was associated with the metabolic syndrome per se, independently of the association with its separate components. The observation that plasma renin activity was associated with some components of the metabolic syndrome, whereas plasma aldosterone was associated with other components of the metabolic syndrome, suggests different underlying mechanisms. These findings reinforce previous observations suggesting that aldosterone is associated with several cardiovascular risk factors and also suggest that aldosterone might contribute to the increased cardiovascular disease risk in individuals of African descent with the metabolic syndrome. © 2006 American Heart Association, Inc.
Authors & Co-Authors
Bochud, Murielle
United States, Cleveland
Case Western Reserve University
Switzerland, Lausanne
Institut Universitaire de Médecine Sociale et Préventive Lausanne
Nüssberger, Juerg
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Bovet, Pascal
Switzerland, Lausanne
Institut Universitaire de Médecine Sociale et Préventive Lausanne
Seychelles, Mahe
Ministry of Health Seychelles
Maillard, Marc P.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Elston, Robert C.
United States, Cleveland
Case Western Reserve University
Paccaud, Fred Michel
Switzerland, Lausanne
Institut Universitaire de Médecine Sociale et Préventive Lausanne
Shamlaye, Conrad F.
Seychelles, Mahe
Ministry of Health Seychelles
Burnier, Michel
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Statistics
Citations: 207
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1161/01.HYP.0000231338.41548.fc
ISSN:
0194911X
Research Areas
Noncommunicable Diseases
Study Locations
Seychelles
Participants Gender
Male
Female