Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Reciprocal regulation of IL-23 and IL-12 following co-activation of dectin-1 and TLR signaling pathways
European Journal of Immunology, Volume 39, No. 5, Year 2009
Notification
URL copied to clipboard!
Description
Recognition ofmicrobial products by germ-line-encoded PRR initiates immune responses, but how PRR mediate specific host responses to infectious agents is poorly understood. We and others have proposed that specificity is achieved by collaborative responsesmediated between different PRR. One such example comprises the fungal β-glucan receptor Dectin-1, which collaborates with TLR to induce TNF production. We show here that collaborative responses mediated by Dectin-1 and TLR2 are more extensive than first appreciated, and result in enhanced IL-23, IL-6 and IL-10 production in DC, while down-regulating IL-12 relative to the levels produced by TLR ligation alone. Such down-regulation occurred with multiple MyD88-coupled TLR, was dependent on signaling through Dectin-1 and also occurred in macrophages. These findings explain how fungi can induce IL-23 and IL-6, while suppressing IL-12, a combination which has previously been shown to contribute to the development of Th17 responses found during fungal infections. Furthermore, these data reveal how the collaboration of different PRR can tailor specific responses to infectious agents. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Dennehy, Kevin M.
South Africa, Cape Town
University of Cape Town
Willment, Janet Anne
South Africa, Cape Town
University of Cape Town
Williams, David L.
United States, Johnson
Quillen-dishner College of Medicine
Brown, Gordon D.A.
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 170
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1002/eji.200838543
e-ISSN:
15214141