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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda
American Journal of Tropical Medicine and Hygiene, Volume 91, No. 1, Year 2014
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Description
Standard therapy for malaria in Uganda changed from chloroquine to chloroquine + sulfadoxine-pyrimethamine in 2000, and artemether-lumefantrine in 2004, although implementation of each change was slow. Plasmodium falciparum genetic polymorphisms are associated with alterations in drug sensitivity. We followed the prevalence of drug resistancemediating P. falciparum polymorphisms in 982 samples from Tororo, a region of high transmission intensity, collected from three successive treatment trials conducted during 2003-2012, excluding samples with known recent prior treatment. Considering transporter mutations, prevalence of the mutant pfcrt 76T, pfmdr1 86Y, and pfmdr1 1246Y alleles decreased over time. Considering antifolate mutations, the prevalence of pfdhfr 51I, 59R, and 108N, and pfdhps 437G and 540E were consistently high; pfdhfr 164L and pfdhps 581G were uncommon, but most prevalent during 2008-2010. Our data suggest sequential selective pressures as different treatments were implemented, and they highlight the importance of genetic surveillance as treatment policies change over time. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4080569/bin/SD2.pdf
Authors & Co-Authors
Mbogo, George W.
Unknown Affiliation
Nankoberanyi, Sheila
Unknown Affiliation
Tukwasibwe, Stephen
Unknown Affiliation
Baliraine, Frederick N.
Unknown Affiliation
Nsobya, Samuel Lubwama
Unknown Affiliation
Conrad, Melissa D.
Unknown Affiliation
Arinaitwe, Emmanuel S.
Unknown Affiliation
Kamya, Moses Robert K.
Unknown Affiliation
Tappero, Jordan W.
Unknown Affiliation
Staedke, Sarah G.
Unknown Affiliation
Dorsey, Grant M.
Unknown Affiliation
Greenhouse, Bryan R.
Unknown Affiliation
Rosenthal, Philip Jon
Unknown Affiliation
Statistics
Citations: 65
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.4269/ajtmh.13-0647
ISSN:
00029637
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Uganda