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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density
Vaccine, Volume 37, No. 30, Year 2019
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Description
Widespread use of Pneumococcal Conjugate Vaccines (PCV) has reduced vaccine-type nasopharyngeal colonisation and invasive pneumococcal disease. In a double-blind, randomised controlled trial using the Experimental Human Pneumococcal Challenge (EHPC) model, PCV-13 (Prevenar-13) conferred 78% protection against colonisation acquisition and reduced bacterial intensity (AUC) as measured by classical culture. We used a multiplex qPCR assay targeting lytA and pneumococcal serotype 6A/B cpsA genes to re-assess the colonisation status of the same volunteers. Increase in detection of low-density colonisation resulted in reduced PCV efficacy against colonisation acquisition (29%), compared to classical culture (83%). For experimentally colonised volunteers, PCV had a pronounced effect on decreasing colonisation density. These results obtained in adults suggest that the success of PCV vaccination could primarily be mediated by the control of colonisation density. Studies assessing the impact of pneumococcal vaccines should allow for density measurements in their design. © 2019 The Authors
Authors & Co-Authors
German, Esther L.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Solórzano, Carla
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Sunny, Syba Susan
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Dunne, Felicity
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Gritzfeld, Jenna F.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Mitsi, Elena
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Nikolaou, Elissavet
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Hyder-Wright, Angela D.
United Kingdom, Liverpool
Royal Liverpool University Hospital
Collins, Andrea M.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Gordon, Stephen B.
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Ferreira, Daniela Mulari
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 14
Authors: 11
Affiliations: 2
Identifiers
Doi:
10.1016/j.vaccine.2019.05.080
ISSN:
0264410X
Research Areas
Disability
Study Design
Randomised Control Trial