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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease
Immunity, Volume 54, No. 6, Year 2021
Notification
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Description
The kinetics of the immune changes in COVID-19 across severity groups have not been rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine analysis, we analyzed serial samples from 207 SARS-CoV2-infected individuals with a range of disease severities over 12 weeks from symptom onset. An early robust bystander CD8+ T cell immune response, without systemic inflammation, characterized asymptomatic or mild disease. Hospitalized individuals had delayed bystander responses and systemic inflammation that was already evident near symptom onset, indicating that immunopathology may be inevitable in some individuals. Viral load did not correlate with this early pathological response but did correlate with subsequent disease severity. Immune recovery is complex, with profound persistent cellular abnormalities in severe disease correlating with altered inflammatory responses, with signatures associated with increased oxidative phosphorylation replacing those driven by cytokines tumor necrosis factor (TNF) and interleukin (IL)-6. These late immunometabolic and immune defects may have clinical implications. © 2021
Authors & Co-Authors
Bergamaschi, Laura
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Mescia, Federica
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Dunmore, Benjamin J.
United Kingdom, Cambridge
Addenbrooke's Hospital
Huhn, Oisín
United Kingdom, Cambridge
Addenbrooke's Hospital
Morgan, Michael D.L.
United Kingdom, Cambridge
Cancer Research uk Cambridge Institute
United Kingdom, Hinxton
European Molecular Biology Laboratory
Wills, Mark R.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Baker, Stephen G.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Döffinger, Rainer
United Kingdom, Cambridge
Addenbrooke's Hospital
Dougan, Gordon J.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Elmer, Anne
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Goodfellow, Ian Gordon
United Kingdom, Cambridge
Addenbrooke's Hospital
Gupta, Ravindra K.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Hosmillo, Myra D.T.
United Kingdom, Cambridge
Addenbrooke's Hospital
Kingston, Nathalie
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Lehner, P. Joseph
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Matheson, Nicholas J.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
United Kingdom, Bristol
Nhs Blood and Transplant
Nicholson, Jeremy K.
Australia, Perth
Murdoch University
Petrunkina, Anna M.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Richardson, Sylvia T.
United Kingdom, Cambridge
University of Cambridge
Saunders, Caroline
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Weekes, Michael P.
United Kingdom, Cambridge
University of Cambridge
Toshner, Mark R.
United Kingdom, Cambridge
Addenbrooke's Hospital
United Kingdom, Cambridge
Royal Papworth Hospital Nhs Foundation Trust
Hess, Christoph
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Switzerland, Basel
Universitätsspital Basel
Switzerland, Basel
Universitat Basel
Bradley, John Richard
United Kingdom, Cambridge
Addenbrooke's Hospital
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Lyons, Paul A.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Smith, Kenneth G.C.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Addenbrooke's Hospital
Bucke, Ashlea
Unknown Affiliation
Calder, Jo
Unknown Affiliation
Canna, Laura
Unknown Affiliation
Dewhurst, Eleanor F.
Unknown Affiliation
Domingo, Jason
Unknown Affiliation
Gleadall, Nicholas S.
Unknown Affiliation
Harris, Julie
Unknown Affiliation
Hewitt, Sarah
Unknown Affiliation
Holmes, E. C.
Unknown Affiliation
Huang, Christopher L.H.
Unknown Affiliation
Jarvis, Isobel
Unknown Affiliation
Kennet, Jane
Unknown Affiliation
Jose, Sherly
Unknown Affiliation
Kourampa, Jenny
Unknown Affiliation
Lyons, Paul A.
Unknown Affiliation
Marioni, John Carlo
Unknown Affiliation
Meadows, Anne
Unknown Affiliation
Papadia, Sofia
Unknown Affiliation
Price, Jane
Unknown Affiliation
Rastall, Rebecca J.
Unknown Affiliation
Ribeiro, Carla G.
Unknown Affiliation
Rowlands, Jane
Unknown Affiliation
Stephens, Jonathan Claiborne
Unknown Affiliation
Stirrups, Kathleen E.
Unknown Affiliation
Summers, Charlotte
Unknown Affiliation
Tordesillas, Hugo
Unknown Affiliation
Townsend, Paul A.
Unknown Affiliation
Turner, Lori
Unknown Affiliation
Statistics
Citations: 148
Authors: 54
Affiliations: 12
Identifiers
Doi:
10.1016/j.immuni.2021.05.010
ISSN:
10747613
Research Areas
Cancer
Covid
Study Design
Cohort Study