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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Comparison of insulin detemir and insulin glargine in subjects with type 1 diabetes using intensive insulin therapy
Diabetic Medicine, Volume 24, No. 6, Year 2007
Notification
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Description
Aims: To compare glycaemic control and risk of hypoglycaemia of twice-daily insulin detemir with once-daily insulin glargine in subjects with Type 1 diabetes. Methods: In this 26-week, multicentre, open-label, parallel-group trial, 320 subjects with Type 1 diabetes received either insulin detemir twice daily or insulin glargine once daily. each in combination with premeal insulin aspart. Results: After 26 weeks, HbA1c had decreased from 8.8 to 8.2% in the insulin detemir group and from 8.7 to 8.2% in the insulin glargine group. Home-measured fasting plasma glucose (PG) was lower with insulin glargine than with insulin detemir (7.0 vs. 7.7 mmol/l, P < 0.001). The overall shape of the home-measured nine-point PG profiles was comparable between treatments (P = 0.125). Overall, there was no significant difference in within-subject variation in PG (P = 0.437). Within-subject variation in predinner PG was lower with insulin detemir than with insulin glargine (P < 0.05). The overall risk of hypoglycaemia was similar with no differences in confirmed hypoglycaemia. However, the risk of severe and nocturnal hypoglycaemia was 72% and 32%, respectively, lower with insulin detemir than with insulin glargine (P < 0.05). Body weight gain was not significantly different comparing insulin detemir and insulin glargine (0.52 kg vs. 0.96 kg, P = 0.193). Conclusions: Treatment with twice-daily insulin detemir or once-daily insulin glargine, each in combination with insulin aspart, resulted in similar glycaemic control. The overall risk of hypoglycaemia was comparable, whereas the risks of both severe and nocturnal hypoglycaemia were significantly lower with insulin detemir. © 2007 The Authors.
Authors & Co-Authors
Pieber, Thomas Rudolf
Austria, Graz
Medizinische Universität Graz
Treichel, H. C.
Germany, Geesthacht
Johanniter Hospital
Hompesch, B.
Germany, Neuss
Profil Gmbh
Philotheou, Areti
South Africa, Cape Town
Faculty of Health Sciences
Mordhorst, L.
Denmark, Bagsvard
Novo Nordisk A/s
Gall, M. A.
Denmark, Bagsvard
Novo Nordisk A/s
Robertson, L. I.
South Africa, Durban
Parklands Medical Centre
Statistics
Citations: 149
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1111/j.1464-5491.2007.02113.x
ISSN:
07423071
e-ISSN:
14645491
Research Areas
Noncommunicable Diseases