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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Molecular analysis of the sex-determining region of the platyfish Xiphophorus maculatus
Zebrafish, Volume 3, No. 3, Year 2006
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Description
Due to the presence of genetically well-defined sex chromosomes, with a relatively restricted sex-determination region containing markers identified at the molecular level, the platyfish Xiphophorus maculatus is one of the best models for the positional cloning of a master sex-determining gene in fish. Both male and female heterogametes and three different types of sex chromosomes have been described in the platyfish, with several loci involved in pigmentation, melanoma formation, and sexual maturity closely linked to the master sex-determining locus. Using the melanoma-inducing oncogene Xmrk, its protooncogenic counterpart egfrb, as well as other X- and Y-linked molecular markers, bacterial artificial chromosome (BAC) contigs have been assembled for the sex-determining region of X. maculatus, which was mapped by fluorescent in situ hybridization to the subtelomeric region of the sex chromosomes. Initial sequence analysis of these contigs revealed several gene candidates and uncovered syntenies with different mammalian and chicken autosomes, supporting an independent origin of sex chromosomes in platyfish and tetrapods. Strikingly, the sex determination region of the platyfish is very instable and frequently undergoes duplications, deletions, and transpositions. This instability might be linked to the high genetic variability affecting sex determination and other sex-linked traits in Xiphophorus. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Schultheis, Christina
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Zhou, Qingchun
Germany, Wurzburg
Julius-maximilians-universität Würzburg
United States, Norman
The University of Oklahoma
Froschauer, Alexander
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Germany, Dresden
Technische Universität Dresden
Nanda, Indrajit
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Selz, Yvonne
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Schmidt, Cornelia
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Matschl, Sabine
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Wenning, Marina
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Veith, Anne Marie
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Naciri, M.
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Morocco, Rabat
Faculté Des Sciences Rabat
Hanel, Reinhold
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Germany, Kiel
Geomar - Helmholtz-zentrum Für Ozeanforschung Kiel
Braasch, Ingo
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Dettai, Agnès
Germany, Wurzburg
Julius-maximilians-universität Würzburg
France, Paris
Museum National D'histoire Naturelle
Böhne, Astrid
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Ozouf-Costaz, Catherine
France, Paris
Museum National D'histoire Naturelle
Chilmonczyk, Stefan
France, Jouy-en-josas
Unité de Virologie et Immunologie Moléculaires
Ségurens, Béatrice
France, Evry
Genoscope - Centre National de Séquençage
Couloux, Arnaud
France, Evry
Genoscope - Centre National de Séquençage
Bernard-Samain, Sylvie
France, Evry
Genoscope - Centre National de Séquençage
Schmid, Michael
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Schartl, Manfred
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Volff, Jean Nicolas
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Statistics
Citations: 31
Authors: 22
Affiliations: 8
Identifiers
Doi:
10.1089/zeb.2006.3.299
ISSN:
15458547
Research Areas
Genetics And Genomics
Sexual And Reproductive Health
Participants Gender
Male
Female