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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Effect of organic-phase solvents on physicochemical properties and cellular uptake of astaxanthin nanodispersions
Journal of Agricultural and Food Chemistry, Volume 59, No. 16, Year 2011
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Description
A simplex centroid mixture design was used to study the interactions between two chosen solvents, dichloromethane (DCM) and acetone (ACT), as organic-phase components in the formation and physicochemical characterization and cellular uptake of astaxanthin nanodispersions produced using precipitation and condensation processes. Full cubic or quadratic regression models with acceptable determination coefficients were obtained for all of the studied responses. Multiple-response optimization predicted that the organic phase with 38% (w/w) DCM and 62% (w/w) ACT yielded astaxanthin nanodispersions with the minimum particle size (106 nm), polydispersity index (0.191), and total astaxanthin loss (12.7%, w/w) and the maximum cellular uptake (2981 fmol/cell). Astaxanthin cellular uptake from the produced nanodispersions also showed a good correlation with their particle size distributions and astaxanthin trans/cis isomerization ratios. The absence of significant (p > 0.05) differences between the experimental and predicted values of the response variables confirmed the adequacy of the fitted models. © 2011 American Chemical Society.
Authors & Co-Authors
Anarjan, Navideh
Malaysia, Serdang
Universiti Putra Malaysia
Tan, Chin Ping
Malaysia, Serdang
Universiti Putra Malaysia
Saudi Arabia, Riyadh
College of Sciences
Ling, Tauchuan
Malaysia, Kuala Lumpur
Institute of Biological Sciences
Lye, Kwan Liang
Malaysia, Serdang
Faculty of Medicine and Health Sciences
Jafarizadeh-Malmiri, Hoda
Malaysia, Serdang
Universiti Putra Malaysia
Nehdi, Imededdine Arbi
Saudi Arabia, Riyadh
College of Sciences
Cheah, Yoke Kqueen
Malaysia, Serdang
Faculty of Medicine and Health Sciences
Hamed, Mirhosseini
Malaysia, Serdang
Universiti Putra Malaysia
Sham Baharin, Badlishah
Malaysia, Serdang
Universiti Putra Malaysia
Statistics
Citations: 50
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1021/jf201314u
ISSN:
00218561
e-ISSN:
15205118