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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus
Journal of Proteome Research, Volume 10, No. 3, Year 2011
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Description
Mortality attributable to infection with methicillin-resistant Staphylococcus aureus (MRSA) has now overtaken the death rate for AIDS in the United States, and advances in research are urgently needed to address this challenge. We report the results of the systematic identification of protein-protein interactions for the hospital-acquired strain MRSA-252. Using a high-throughput pull-down strategy combined with quantitative proteomics to distinguish specific from nonspecific interactors, we identified 13-219 interactions involving 608 MRSA proteins. Consecutive analyses revealed that this protein interaction network (PIN) exhibits scale-free organization with the characteristic presence of highly connected hub proteins. When clinical and experimental antimicrobial targets were queried in the network, they were generally found to occupy peripheral positions in the PIN with relatively few interacting partners. In contrast, the hub proteins identified in this MRSA PIN that are essential for network integrity and stability have largely been overlooked as drug targets. Thus, this empirical MRSA-252 PIN provides a rich source for identifying critical proteins essential for network stability, many of which can be considered as prospective antimicrobial drug targets. © 2010 American Chemical Society.
Authors & Co-Authors
Cherkasov, Artem R.
Canada, Vancouver
The University of British Columbia
Canada, Burnaby
Simon Fraser University
Zoraghi, Roya
Canada, Vancouver
The University of British Columbia
Foster, Leonard J.
Canada, Vancouver
The University of British Columbia
See, Raymond H.
Canada, Vancouver
The University of British Columbia
Kaur, Sukhbir
Canada, Vancouver
The University of British Columbia
Gong, Huansheng
Canada, Vancouver
The University of British Columbia
Swayze, Richard D.
Canada, Vancouver
The University of British Columbia
Hormozdiari, Farhad
Canada, Burnaby
Simon Fraser University
Axerio-Cilies, Peter
Canada, Vancouver
The University of British Columbia
McMaster, W. Robert
Canada, Vancouver
The University of British Columbia
Brunham, Robert C.
Canada, Vancouver
The University of British Columbia
Finlay, Barton Brett
Canada, Vancouver
The University of British Columbia
Reiner, Neil E.
Canada, Vancouver
The University of British Columbia
Statistics
Citations: 58
Authors: 13
Affiliations: 2
Identifiers
Doi:
10.1021/pr100918u
ISSN:
15353907
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Study Approach
Quantitative