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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Increased Vascularity in Cervicovaginal mucosa with Schistosoma haematobium infection
PLoS Neglected Tropical Diseases, Volume 5, No. 6, Article e1170, Year 2011
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Description
Background: Close to 800 million people in the world are at risk of schistosomiasis, 85 per cent of whom live in Africa. Recent studies have indicated that female genital schistosomiasis might increase the risk of human immunodeficiency virus (HIV) infection. The aim of this study is to quantify and analyse the characteristics of the vasculature surrounding Schistosoma haematobium ova in the female genital mucosa. Methodology/Principal Findings: Cervicovaginal biopsies with S. haematobium ova (n = 20) and control biopsies (n = 69) were stained with immunohistochemical blood vessel markers CD31 and von Willebrand Factor (vWF), which stain endothelial cells in capillary buds and established blood vessels respectively. Haematoxylin and eosin (HE) were applied for histopathological assessment. The tissue surrounding S. haematobium ova had a higher density of established blood vessels stained by vWF compared to healthy controls (p = 0.017). Immunostain to CD31 identified significantly more granulation tissue surrounding viable compared to calcified ova (p = 0.032), and a tendency to neovascularisation in the tissue surrounding viable ova compared to healthy cervical mucosa (p = 0.052). Conclusions/Significance: In this study female genital mucosa with S. haematobium ova was significantly more vascularised compared to healthy cervical tissue. Viable parasite ova were associated with granulation tissue rich in sprouting blood vessels. Although the findings of blood vessel proliferation in this study may be a step to better understand the implications of S. haematobium infection, further studies are needed to explore the biological, clinical and epidemiological features of female genital schistosomiasis and its possible influence on HIV susceptibility. © 2011 Jourdan et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3110160/bin/pntd.0001170.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3110160/bin/pntd.0001170.s002.tif
Authors & Co-Authors
Jourdan, Peter Mark
Norway, Oslo
Ulleval University Hospital
Norway, Oslo
Universitetet I Oslo
Roald, Borghild Barth Heyerdahl
Norway, Oslo
Universitetet I Oslo
Norway, Oslo
Ulleval University Hospital
Poggensee, Gabriele
Germany, Berlin
Robert Koch Institute
Gundersen, Svein Gunnar
Norway, Kristiansand
Sørlandet Hospital hf
Norway, Kristiansand
Universitetet I Agder
Kjetland, Eyrun Floerecke
Norway, Oslo
Ulleval University Hospital
Statistics
Citations: 66
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pntd.0001170
ISSN:
19352735
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Female