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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica
Veterinary Parasitology, Volume 158, No. 4, Year 2008
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Description
The medicinal plant Brucea javanica (L.) Merr. (Simaroubaceae) is widely distributed throughout Asia where its bitter fruits have been used in traditional medicine for various ailments. Fifteen C-20 quassinoids were isolated from the fruits of B. javanica and examined for their in vitro antitrypanosomal activities against trypomastigotes of Trypanosoma evansi. Bruceine A, bruceantinol, bruceine C, brusatol, and bruceine B showed strong antitrypanosomal activities with IC50 values in the range of 2.9-17.8 nM, which compared well with the standard trypanocidal drugs diminazene aceturate (IC50 = 8.8 nM) and suramin (IC50 = 43.2 nM). However, dehydrobruceine A, dehydrobruceine B, and dehydrobrusatol were about 2100, 900, and 1200 times less active, respectively, than bruceine A, bruceine B, and brusatol. The relationship of the structure and antitrypanosomal activity of these quassinoid compounds suggested that the presence of a diosphenol moiety in ring A and the nature of the C-15 side chain are important for their activities against T. evansi. This is the first report on the antitrypanosomal activity of isolated quassinoids. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Bawm, Saw
Japan, Sapporo
Graduate School of Veterinary Medicine
Matsuura, Hideyuki
Japan, Sapporo
Hokkaido University
Elkhateeb, Ahmed M.
Japan, Sapporo
Hokkaido University
Nonaka, Nariaki
Japan, Sapporo
Graduate School of Veterinary Medicine
Oku, Yuusaburo
Japan, Sapporo
Graduate School of Veterinary Medicine
Katakura, Ken
Japan, Sapporo
Graduate School of Veterinary Medicine
Statistics
Citations: 53
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.vetpar.2008.09.021
ISSN:
03044017
Research Areas
Health System And Policy