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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV progression and predictors of mortality in a community-based cohort of Zambian adults
Journal of the International Association of Physicians in AIDS Care, Volume 7, No. 1, Year 2008
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Description
This article describes immunological HIV progression, mortality, and its predictors in 974 Zambian adults. During 3138 person-years of follow-up, 281 deaths occurred, and the overall mortality rate was 9.0 per 100 person-years. Thirty-six percent of patients were dead within 5 years of enrollment. The median survival in patients with baseline CD4 count <500 cells/mm 3 was 5.62 years, with CD4 count between 200 and 499 cells/mm 3 5.46 years, and with CD4 count <200 cells/mm 3 3.89 years. The mortality rate increased significantly with older age (6.9 in patients <25 years, 9.3 in individuals aged 25-39 years, 10.2 in patients <40 years) and was higher in women (rate ratio 1.29). The median annual change of progression markers was -29.6 cells/mm 3 for CD4 count, -3.0% for CD4 count percentage, 1.2 nmol/L for neopterin, -1.9 g/L for hemoglobin, and -70 cells/ mm 3 for total lymphocyte count. Hemoglobin and neopterin were as accurate as CD4 count to predict mortality. © 2008 Sage Publications.
Authors & Co-Authors
Kitchen, Maria
Unknown Affiliation
Quigley, Maria A.
Unknown Affiliation
Mwinga, Alwyn G.
Unknown Affiliation
Fuchs, Dietmar N.
Unknown Affiliation
Lisse, Ida Maria
Unknown Affiliation
Porter, John D.H.
Unknown Affiliation
McAdam, Keith P.W.J.
Unknown Affiliation
Godfrey-Faussett, P. D.
Unknown Affiliation
Statistics
Citations: 8
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1177/1545109707303989
ISSN:
15451097
e-ISSN:
15570886
Research Areas
Infectious Diseases
Study Design
Cohort Study
Participants Gender
Female