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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity
Journal of Infectious Diseases, Volume 186, No. 10, Year 2002
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Description
Tuberculosis (TB) vaccine development is hindered by the lack of clear surrogate markers of protective human immunity to Mycobacterium tuberculosis. This study evaluated the hypothesis that immune-mediated inhibition of mycobacterial growth would more directly correlate with protective TB immunity than other immunologic responses. Bacille Calmette-Guérin (BCG) vaccination, known to induce partial protection against TB, was used as a model system to investigate mechanistic relationships among different parameters of antigen-specific immunity. Effects of primary and booster intradermal BCG vaccinations were assessed in 3 distinct assays of mycobacterial inhibition. Correlations between vaccine-induced growth inhibition and other immune responses were analyzed. BCG significantly enhanced all antigen-specific responses. Peak responses occurred at 2 months after boosting. Statistical analyses suggested that each assay measured unique aspects of mycobacterial immunity. Despite previous evidence that type 1 immune responses are essential for TB immunity, interferon-γ production did not correlate with mycobacterial inhibition. These results have important implications for TB vaccine development. © Oxford University Press 2001.
Authors & Co-Authors
Hoft, Daniel Fredric
United States, St. Louis
Saint Louis University
Worku, Shewangizaw
United States, St. Louis
Saint Louis University
Kampmann, Beate B.
United Kingdom, London
Imperial College London School of Medicine
Whalen, Christopher Curtis
United States, Cleveland
Case School of Medicine
Ellner, Jerrold J.
United States, Newark
Rutgers Biomedical and Health Sciences
Hirsch, Christina S.
United States, Cleveland
Case School of Medicine
Yun, Hyun
United States, Cleveland
Case School of Medicine
Silver, Richard F.
United States, Cleveland
Case School of Medicine
Statistics
Citations: 115
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1086/344359
ISSN:
00221899
Research Areas
Infectious Diseases