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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
A natural focus of Histoplasma capsulatum var. duboisii is a bat cave
Mycopathologia, Volume 127, No. 3, Year 1994
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Description
The natural reservoir of Histoplasma capsulatum var. duboisii, the etiological agent of histoplasmosis duboisii (African histoplasmosis) is not yet known. We report the isolation of H. capsulatum var. duboisii from soil admixed with bat guano and from the intestinal contents of a bat in a sandstone cave in a rural area, Ogbunike in Anambra State of Nigeria. Eight of 45 samples of soil admixed with bat guano yielded H. capsulatum var. duboisii. Of the 35 bats belonging to the species Nycteris hispida and Tadirida pumila examined, only one (N. hispida) yielded this fungus from its intestinal contents. Identification of the isolates as Histoplasma was confirmed by exoantigen tests and by mating with tester strains of H. capsulatum. In vitro conversion to large yeast from suggestive of H. capsulatum var. duboisii was obtained on brain heart infusion agar supplemented with sheep blood and glutamine or cysteine. Pathogenicity tests with mice for all the isolates confirmed their identity by the demonstration of large yeast forms (8-15 μm in diameter) within giant cells in the infected tissues. Investigations on the possible occurrence of human infections in the area are in progress. © 1994 Kluwer Academic Publishers.
Authors & Co-Authors
Gugnani, Harish Chander C.
Nigeria, Naukka
University of Nigeria
Muotoe-Okafor, Florence A.
Nigeria, Naukka
University of Nigeria
Kaufman, Leo
United States, Atlanta
Centers for Disease Control and Prevention
Dupont, Bertrand F.
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 35
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1007/BF01102915
ISSN:
0301486X
e-ISSN:
15730832
Study Locations
Nigeria