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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
6.26 Phenotypic analysis of bovine leukocyte cell lines infected with Theileria annulata
Veterinary Immunology and Immunopathology, Volume 39, No. 1-3, Year 1993
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Description
Six cell lines that were infected with Theileria annulata were compared for expression of a range of surface molecules. Immunofluorescence staining with the panel of monoclonal antibodies formulated for the Second Workshop was analysed by flow cytometry. Four lines generated from bovine peripheral blood mononuclear cells by exposure to sporozoites in vitro and one line generated in vivo from an infected calf were phenotypically similar. Phenotypic analysis of those lines did not demonstrate a monocyte or B cell origin, but indicated they were not derived from T cells. An uncloned line generated in vivo from an infected calf was CD3+ and γ/δ TCR+. The results indicate that a wider range of host cell types may be infected in vivo than suspected hitherto and that some of the cells may express an abnormal pattern of surface molecules. Both could have profound consequences for the pathogenesis of T. annulata infection. © 1993.
Authors & Co-Authors
Howard, Christopher John
United Kingdom, Swindon
Biotechnology and Biological Sciences Research Council
Sopp, Paul
United Kingdom, Swindon
Biotechnology and Biological Sciences Research Council
Preston, Patricia M.
United Kingdom, Edinburgh
Inst. of Cell
Jackson, Louise A.
United Kingdom, Edinburgh
Inst. of Cell
Brown, C. G.Duncan
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 16
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/0165-2427(93)90189-B
ISSN:
01652427