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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Genomic epidemiology of Streptococcus pneumoniae serotype 16F lineages
Microbial Genomics, Volume 9, No. 11, Article 001123, Year 2023
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Description
Due to the emergence of non-vaccine serotypes in vaccinated populations, Streptococcus pneumoniae remains a major global health challenge despite advances in vaccine development. Serotype 16F is among the predominant non-vaccine serotypes identified among vaccinated infants in South Africa (SA). To characterize lineages and antimicrobial resistance in 16F isolates obtained from South Africa and place the local findings in a global context, we analysed 10 923 S. pneumoniae carriage isolates obtained from infants recruited as part of a broader SA birth cohort. We inferred serotype, resistance profile for penicillin, chloramphenicol, cot-rimoxazole, erythromycin and tetracycline, and global pneumococcal sequence clusters (GPSCs) from genomic data. To ensure global representation, we also included S. pneumoniae carriage and disease isolates from the Global Pneumococcal Sequencing (GPS) project database (n=19 607, collected from 49 countries across 5 continents, 1995–2018, accessed 17 March 2022). Nine per cent (934/10923) of isolates obtained from infants in the Drakenstein community in SA and 2 %(419/19607) of genomes in the GPS dataset were serotype 16F. Serotype 16F isolates were from 28 different lineages of S. pneumoniae, with GPSC33 and GPSC46 having the highest proportion of serotype 16F isolates at 26 % (346/1353) and 53 % (716/1353), respectively. Serotype 16F isolates were identified globally, but most isolates were collected from Africa. GPSC33 was associated with carriage [OR (95 % CI) 0.24 (0.09–0.66); P=0.003], while GPSC46 was associated with disease [OR (95 % CI) 19.9 (2.56–906.50); P=0.0004]. Ten per cent (37/346) and 15 % (53/346) of isolates within GPSC33 had genes associated with resistance to penicillin and co-trimoxazole, respectively, and 18 % (128/716) of isolates within GPSC46 had genes associated with resistance to co-trimoxazole. Resistant isolates formed genetic clusters, which may suggest emerging resistant lineages. Serotype 16F lineages were common in southern Africa. Some of these lineages were associated with disease and resistance to penicillin and cotrimoxazole. We recommend continuous genomic surveillance to determine the long-term impact of serotype 16F lineages on vaccine efficacy and antimicrobial therapy globally. Investing in vaccine strategies that offer protection over a wide range of serotypes/lineages remains essential. This paper contains data hosted by Microreact. © 2023 The Authors.
Authors & Co-Authors
Mokaya, Jolynne
United Kingdom, Hinxton
Wellcome Sanger Institute
Mellor, Kate C.
United Kingdom, Hinxton
Wellcome Sanger Institute
Murray, Gemma G.R.
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, London
University College London
Kalizang’oma, Akuzike
United Kingdom, London
University College London
Malawi, Blantyre
Malawi-liverpool-wellcome Trust Clinical Research Programme
Lekhuleni, Cebile
South Africa, Johannesburg
National Health Laboratory Service
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Zar, Heather J.
South Africa, Tygerberg
South African Medical Research Council
Nicol, Mark P.
Australia, Perth
The University of Western Australia
McGee, Lesley
United States, Atlanta
Centers for Disease Control and Prevention
Bentley, Stephen D.
United Kingdom, Hinxton
Wellcome Sanger Institute
Lo, Stephanie W.
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Bath
University of Bath
Dube, Felix S.
South Africa, Cape Town
University of Cape Town
Zambia, Lusaka
University of Lusaka
Statistics
Authors: 11
Affiliations: 11
Identifiers
Doi:
10.1099/mgen.0.001123
ISSN:
20575858
Research Areas
Genetics And Genomics
Study Design
Cohort Study
Study Locations
South Africa