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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
arts and humanities
Mean intraocular pressure and progression based on corneal thickness in patients with ocular hypertension
Eye, Volume 23, No. 1, Year 2009
Notification
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Description
Purpose: To determine the incidence of glaucomatous progression at mean intraocular pressure (IOP) levels in patients with ocular hypertension (OHT). Methods: A retrospective, multicentre, cohort analysis of 230 OHT patients with 5 years of follow-up evaluated for risk factors associated with progressive optic disc and visual field loss to determine the incidence of glaucomatous progression. Results: Forty percent of patients with IOPs ≥24 mmHg, 18% of patients with IOPs of 21-23 mmHg, 11% of patients with IOPs with 18-20 mmHg, and 3% of patients with IOPs of ≤17 mmHg progressed to glaucoma. The mean IOP was 19.8±2.4 mmHg in the stable group and 21.7±2.6 mmHg in the progressed group (P=0.0004). The highest average peak IOP was 23.4±4.0 mmHg in the stable group and 25.2±3.1 mmHg in the progressed group (P=0.006). Based on the pachymetry values for central corneal thickness, patients with thinner corneas more often progressed to glaucoma (P<0.0001). A multivariant regression analysis to determine risk factors for progression was positive primarily for higher peak IOPs, older age, male gender, argon laser trabeculoplasty, visual acuity ≥20/50, and no topical medical therapy or β-blocker therapy prior to the study. Conclusions: IOP reduction within the normal range over 5 years of follow-up reduces the chance of progression to primary open-angle glaucoma in OHT patients. © 2009 Macmillan Publishers Limited All rights reserved.
Authors & Co-Authors
Konstas, A. G.P.
Greece, Thessaloniki
University General Hospital of Thessaloniki Ahepa
Irkec, M. Tanju
Turkey, Ankara
Hacettepe Üniversitesi
Teus, M. A.
Spain, Alicante
Vissum Corporación Oftalmologica
Cvenkel, B.
Slovenia, Ljubljana
Univerzitetni Klinični Center Ljubljana
Astakhov, Yury Sergueevich
Russian Federation, Saint Petersburg
Pavlov University
Sharpe, E. D.
United States, Mt Pleasant
Glaucoma Consultants and Center for Eye Research
Hollo, G.
Hungary, Budapest
Semmelweis Egyetem
Mylopoulos, N.
Greece, Thessaloniki
University General Hospital of Thessaloniki Ahepa
Bozkurt, Banu
Unknown Affiliation
Pizzamiglio, C.
Spain, Alicante
Vissum Corporación Oftalmologica
Potyomkin, V. V.
Russian Federation, Saint Petersburg
Pavlov University
Alemu, Abiye M.
Ethiopia, Addis Ababa
Ras Desta Hospital
Nasser, Q. J.
United States, Dallas
Prn Pharmaceutical Research Network, Llc.
Stewart, Jeanette A.
United States, Dallas
Prn Pharmaceutical Research Network, Llc.
Stewart, William C.
United States, Dallas
Prn Pharmaceutical Research Network, Llc.
United States, Columbia
University of South Carolina
Statistics
Citations: 30
Authors: 15
Affiliations: 10
Identifiers
Doi:
10.1038/sj.eye.6702995
ISSN:
0950222X
e-ISSN:
14765454
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Male