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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Human retrovirus codon usage from tRNA point of view: Therapeutic insights
Bioinformatics and Biology Insights, Volume 7, Year 2013
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Description
The purpose of this study was to investigate the balance between transfer ribonucleic acid (tRNA) supply and demand in retrovirus-infected cells, seeking the best targets for antiretroviral therapy based on the hypothetical tRNA Inhibition Therapy (TRIT). Codon usage and tRNA gene data were retrieved from public databases. Based on logistic principles, a therapeutic score (T-score) was calculated for all sense codons, in each retrovirus-host system. Codons that are critical for viral protein translation, but not as critical for the host, have the highest T-score values. Theoretically, inactivating the cognate tRNA species should imply a severe reduction of the elongation rate during viral mRNA translation. We developed a method to predict tRNA species critical for retroviral protein synthesis. Four of the best TRIT targets in HIV-1 and HIV-2 encode Large Hydrophobic Residues (LHR), which have a central role in protein folding. One of them, codon CUA, is also a TRIT target in both HTLV-1 and HTLV-2. Therefore, a drug designed for inactivating or reducing the cytoplasmatic concentration of tRNA species with anticodon TAG could attenuate signifcantly both HIV and HTLV protein synthesis rates. Inversely, replacing codons ending in UA by synonymous codons should increase the expression, which is relevant for DNA vaccine design. © the author(s), publisher and licensee Libertas Academica Ltd.
Authors & Co-Authors
Frias, Diego
Brazil, Salvador
Universidade do Estado da Bahia
Monteiro-Cunha, Joana P.
Brazil, Salvador
Universidade Federal da Bahia
Brazil, Salvador
Escola Bahiana de Medicina e Saúde Pública – Ebmsp
Mota-Miranda, Aline Cristina Andrade
Brazil, Salvador
Universidade Federal da Bahia
Brazil, Salvador
Escola Bahiana de Medicina e Saúde Pública – Ebmsp
Fonseca, Vagner S.
Brazil, Salvador
Universidade do Estado da Bahia
De Oliveira, Tulio
South Africa, Durban
University of Kwazulu-natal
Galvão-Castro, Bernardo
Brazil, Salvador
Escola Bahiana de Medicina e Saúde Pública – Ebmsp
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Junior Alcantara, Luiz Carlos
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Statistics
Citations: 7
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.4137/BBI.S12093
e-ISSN:
11779322
Research Areas
Genetics And Genomics
Infectious Diseases