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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Physicochemical properties and x‐ray structural studies of the trigonal polymorph of carbamazepine
Journal of Pharmaceutical Sciences, Volume 76, No. 9, Year 1987
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Description
The trigonal polymorph of carbamazepine (α‐carbamazepine) was obtained by crystallization from a number of solvents. It was characterized by means of differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, X‐ray powder diffraction, thermal microscopy, and powder and intrinsic dissolution rates. The crystal and molecular structures were determined by single‐crystal, three dimensional X‐ray analysis. A comparison is drawn between the physicochemical properties of the monoclinic (β) and trigonal (α) forms. Structural features of carbamazepine occurring in these forms and in the acetone solvate are compared. Substantial differences were detected between the two polymorphic forms with regard to infrared and differential scanning calorimetry data, thermomicroscopical behavior, morphology, and molecular conformation. Copyright © 1987 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Lowes, Mariette M.J.
South Africa, Potchefstroom
North-west University
Caira, Mino R.
South Africa, Gqeberha
Nelson Mandela University
Lötter, Antonie P.
South Africa, Potchefstroom
North-west University
Van Watt, Jakkie G.Der
South Africa, Potchefstroom
North-west University
Statistics
Citations: 189
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1002/jps.2600760914
ISSN:
00223549
e-ISSN:
15206017