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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Hypothyroidism induces type I iodothyronine deiodinase expression in tilapia liver
General and Comparative Endocrinology, Volume 124, No. 3, Year 2001
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Description
In the current study, the authors examined the effects of experimentally induced hypothyroidism on peripheral thyroid hormone metabolism and growth in two closely related tilapia species: the Nile tilapia (Oreochromis niloticus) and the slower growing black tilapia (Sarotherodon melanotheron). Hypothyroidism, induced by administration of 0.2% methimazole through the food, significantly decreased plasma T3 and T4 in both species. This decrease in circulating thyroid hormones was accompanied by an increase in hepatic type II deiodinase (D2) and a decrease in hepatic type III deiodinase (D3). Hepatic type I deiodinase (D1), which is barely expressed in euthyroid tilapia, was significantly upregulated during hypothyroidism. The changes in hepatic D1 and D2 enzyme activity were paralleled by changes in D1 and D2 mRNA levels, indicating pretranslational regulation. Hypothyroidism also resulted in severe growth retardation that was accompanied by an increase in condition factor. Because hyperthyroidism has been shown to decrease the condition factor, these results suggest that thyroid hormones play an essential role in the control of proportional body growth in fish. The authors conclude that (1) hepatic D1 expression is induced by hypothyroidism in tilapia, (2) the changes in hepatic iodothyronine deiodinases during hypothyroidism in tilapia are predominantly regulated at a pretranslational level, and (3) thyroid hormones are involved in the control of proportional body growth in fish. © 2001 Elsevier Science.
Authors & Co-Authors
van der Geyten, Serge
Belgium, Leuven
Ku Leuven
Toguyéni, Aboubacar
Belgium, Leuven
Ku Leuven
Burkina Faso, Bobo-dioulasso
Université Nazi Boni
France, Le Rheu
Centre Inrae Bretagne-normandie
Baroiller, Jean François
France, Le Rheu
Centre Inrae Bretagne-normandie
Fauconneau, Benoît
France, Le Rheu
Centre Inrae Bretagne-normandie
Fostier, Alexis Y.
France, Le Rheu
Centre Inrae Bretagne-normandie
Sanders, Jo P.
Netherlands, Rotterdam
Erasmus Mc
Visser, Theo J.
Netherlands, Rotterdam
Erasmus Mc
Kühn, Edouard R.
Belgium, Leuven
Ku Leuven
Darras, Veerle M.
Belgium, Leuven
Ku Leuven
Statistics
Citations: 93
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1006/gcen.2001.7722
Research Areas
Food Security