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Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size

Clinical Infectious Diseases, Volume 73, No. 8, Year 2021

Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.

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Ismail, Sherazaan D.
1. South Africa, Cape Town University of Cape Town
Riou, Catherine
1. South Africa, Cape Town University of Cape Town
Joseph, Sarah Beth
1. United States, Chapel Hill The University of North Carolina at Chapel Hill
Archin, Nancie M.
1. United States, Chapel Hill The University of North Carolina at Chapel Hill
Margolis, David M.
1. United States, Chapel Hill The University of North Carolina at Chapel Hill
Perelson, Alan S.
1. United States, Los Alamos Los Alamos National Laboratory
Cassidy, Tyler
1. United States, Los Alamos Los Alamos National Laboratory
Rose-Abrahams, Melissa
1. South Africa, Cape Town University of Cape Town
Moeser, Matthew
1. United States, Chapel Hill The University of North Carolina at Chapel Hill
Council, Olivia D.
1. United States, Chapel Hill The University of North Carolina at Chapel Hill
McKinnon, Lyle R.
1. South Africa, Durban University of Kwazulu-natal
2. Canada, Winnipeg University of Manitoba
Osman, Farzana
1. South Africa, Durban University of Kwazulu-natal
Abdool Karim, Quarraisha Abdool
1. South Africa, Durban University of Kwazulu-natal
2. United States, New York Mailman School of Public Health
Abdool Karim, Salim S.
1. South Africa, Durban University of Kwazulu-natal
2. United States, New York Mailman School of Public Health
Swanstrom, Ronald I.
1. United States, Chapel Hill The University of North Carolina at Chapel Hill
Williamson, Carolyn
1. South Africa, Cape Town University of Cape Town
2. South Africa, Durban University of Kwazulu-natal
Garrett, Nigel J.
1. South Africa, Durban University of Kwazulu-natal
Burgers, Wendy A.
1. South Africa, Cape Town University of Cape Town

AFRICAN RESEARCH NEXUS

Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size

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AFRICAN RESEARCH NEXUS

Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size

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African Research Nexus

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