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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to tuberculosis
Journal of Infectious Diseases, Volume 205, No. 7, Year 2012
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Description
Background. We studied the association between iron intake and polymorphisms in the iron transporter gene SLC40A1 and the risk of tuberculosis. Methods. We compared iron intake, the frequency of SLC40A1 mutations, and interactions among these variables among 98 tuberculosis patients and 125 controls in Kwazulu-Natal, South Africa. Results. Four SLC40A1 single-nucleotide polymorphisms (SNPs) were associated with an increased risk of tuberculosis and 1 SNP with reduced risk. We also found a gene-environment interaction for 4 nonexonic SNPs and iron intake. Conclusions. This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence of an interaction between dietary iron and SLC40A1. © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Baker, Meghan A.
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Harvard Medical School
Wilson, Douglas P.K.
South Africa, Durban
University of Kwazulu-natal
Wallengren, Kristina
United States, Boston
Harvard T.h. Chan School of Public Health
South Africa, Durban
University of Kwazulu-natal
Sandgren, Andreas
United States, Boston
Harvard T.h. Chan School of Public Health
Sweden, Solna
European Centre for Disease Prevention and Control
Iartchouk, Oleg
United States, Boston
Partners Healthcare
Broodie, Nisha
United States, New York
Vagelos College of Physicians and Surgeons
Goonesekera, Sunali D.
United States, Boston
Harvard T.h. Chan School of Public Health
Sabeti., Pardis C.
United States, Cambridge
Harvard University
United States, Cambridge
Broad Institute
Murray, Megan B.
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Brigham and Women's Hospital
Statistics
Citations: 15
Authors: 9
Affiliations: 10
Identifiers
Doi:
10.1093/infdis/jis026
ISSN:
00221899
Research Areas
Genetics And Genomics
Study Locations
South Africa