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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Concordance of programmatic and laboratory-based multidrug-resistant tuberculosis treatment outcomes in Peru
International Journal of Tuberculosis and Lung Disease, Volume 16, No. 3, Year 2012
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Description
BACKGROUND: Confirmation of cure for multidrugresistant tuberculosis (MDR-TB) patients requires laboratory tests for Mycobacterium tuberculosis growth on culture media. Outcome decisions dictate patient management, and inaccuracies place patients at an increased risk of morbidity and mortality, and may contribute to continued transmission of MDR-TB. OBJECTIVE: To examine concordance between programmatic and laboratory-based MDR-TB treatment outcomes. METHODS: The study population included 1658 MDRTB patients in Peru treated between 1996 and 2002 with both program and laboratory-based outcomes. Laboratory-based outcomes were assigned according to international standards requiring at least five consecutive negative cultures in the last 12 months of treatment to confirm cure. RESULTS: Compared to the global culture-defined standard classification, only 1.1% of treatment successes, but 54.3% of failures, were misclassified programmatically. Overall, 10.4% of patients identified by a clinician as having a successful treatment outcome still had cultures positive for MDR-TB. CONCLUSION: Most patients with successful treatment outcomes by strict culture definitions were also classified by clinicians as having successful outcomes. However, many culture-confirmed failures were missed. In light of delays and incomplete access to culture in MDR-TB programs, efforts should be made to improve the accuracy of programmatically determined treatment outcomes. © 2012 The Union.
Authors & Co-Authors
Podewils, Laura Jean
United States, Atlanta
Centers for Disease Control and Prevention
Mitnick, Carole Diane
United States, Boston
Harvard Medical School
Peru, Lima
Socios en Salud Lima
Becerra, Mercedes C.
United States, Boston
Harvard Medical School
Peru, Lima
Socios en Salud Lima
Laserson, Kayla F.
United States, Atlanta
Emory University
Bonilla Asalde, Cesar Antonio
Peru, Lima
Hospital Nacional Daniel Alcides Carrión
Statistics
Citations: 5
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.5588/ijtld.11.0511
ISSN:
10273719
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study