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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Ten-year experience of cutaneous and/or subcutaneous infections due to coelomycetes in France
Open Forum Infectious Diseases, Volume 3, No. 2, Year 2016
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Description
Background. Coelomycetes are rarely but increasingly reported in association with human infections involving mostly skin and subcutaneous tissues, both in immunocompetent and immunocompromised patients. Coelomycetes constitute a heterogeneous group of filamentous fungi with distinct morphological characteristics in culture, namely an ability to produce asexual spores within fruit bodies.Methods. We included all cases of proven primary cutaneous and/or subcutaneous infections due to coelomycetes received for identification at the French National Reference Center for Invasive Mycoses and Antifungals between 2005 and 2014. Eumycetoma, chromoblastomycosis, and disseminated infections were excluded.Results. Eighteen cases were analyzed. The median age was 60.5 years. In all cases, patients originated from tropical or subtropical areas. An underlying immunodepression was present in 89% of cases. Cutaneous and/or subcutaneous lesions, mainly nodules, abscesses, or infiltrated plaques, were observed in distal body areas. Isolates of different genera of coelomycetes were identified: Medicopsis (6), Paraconiothyrium (3), Gloniopsis (3), Diaporthe (3), Peyronellaea (2), Lasiodiplodia (1). Lesion treatment consisted of complete (10) or partial (2) surgical excision and/or the use of systemic antifungal therapy, namely voriconazole (5) and posaconazole (4). Literature review yielded 48 additional cases of cutaneous and/or subcutaneous infections due to coelomycetes.Conclusions. Infectious diseases physicians should suspect coelomycetes when observing cutaneous and/or subcutaneous infections in immunocompromised hosts from tropical areas; a sequence-based approach is crucial for strains identification but must be supported by consistent phenotypic features; surgical treatment should be favored for solitary, well limited lesions; new triazoles may be used in case of extensive lesions, especially in immunocompromised patients. © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4943527/bin/supp_3_2_ofw106__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4943527/bin/supp_ofw106_ofw106supp.docx
Authors & Co-Authors
García-Hermoso, Dea
France, Paris
Institut Pasteur, Paris
France, Paris
Cnrs Centre National de la Recherche Scientifique
Ahmed, Sarah A.
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Dromer, Françoise
France, Paris
Institut Pasteur, Paris
France, Paris
Cnrs Centre National de la Recherche Scientifique
Lortholary, Olivier
France, Paris
Institut Pasteur, Paris
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
Dunand, Jean
Unknown Affiliation
Moulonguet, Luc
Unknown Affiliation
Bienvenu, Anne Lise
Unknown Affiliation
Desbois, Nicole
Unknown Affiliation
Méniane, Jean Côme
Unknown Affiliation
Cassaing, Sophie
Unknown Affiliation
Guitard, Juliette
Unknown Affiliation
Dupin, Nicolas
Unknown Affiliation
Paugam, André
Unknown Affiliation
Bougnoux, Marie Élisabeth
Unknown Affiliation
Charlier, Caroline M.
Unknown Affiliation
Fekkar, Arnaud
Unknown Affiliation
Alanio, Alexandre
Unknown Affiliation
Bretagne, Stéphane
Unknown Affiliation
Gallien, Sébastien
Unknown Affiliation
Raffoux, Emmanuel
Unknown Affiliation
Françès, Carnille
Unknown Affiliation
Statistics
Citations: 29
Authors: 21
Affiliations: 7
Identifiers
Doi:
10.1093/ofid/ofw106
ISSN:
23288957
Research Areas
Health System And Policy
Study Approach
Systematic review