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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Risk factors for very preterm delivery and delivery of very-small-for- gestational-age infants among HIV-exposed and HIV-unexposed infants in Botswana
International Journal of Gynecology and Obstetrics, Volume 115, No. 1, Year 2011
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Description
Objective: To evaluate risk factors for very preterm delivery (VPTD) and very-small-for-gestational-age (VSGA) births in a country with a high HIV prevalence. Methods: Obstetric records at 6 hospitals across Botswana were reviewed at delivery; VPTD was defined as birth before 32 weeks of pregnancy and VSGA as birth weight below the 3rd percentile for Botswana-specific norms. Results: Of 16 219 live births born after 26 weeks of pregnancy, 701 (4.3%) were delivered very preterm and 607 (3.7%) were VSGA; 4347 (28.4%) were documented as HIV-exposed. In a multivariable analysis, HIV infection and hypertension during pregnancy were associated with a VPTD (adjusted odds ratio [AOR]: HIV 1.65, hypertension 1.75) and a VSGA birth (AOR: HIV infection 1.90, hypertension 3.44). Among HIV-infected women, the continuation of highly active antiretroviral therapy (HAART) from before conception was associated with a VSGA birth (AOR 1.75) but not with a VPTD (AOR 0.78). In a secondary analysis, HAART continuation was associated with hypertension during pregnancy (AOR 1.34). Conclusion: Hypertension and HIV infection were risk factors for a VPTD and a VSGA birth. Continuation of HAART from before conception was associated with a VSGA birth but not with a VPTD. © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Parekh, Natasha K.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
Ribaudo, Heather J.
United States, Boston
Harvard T.h. Chan School of Public Health
Souda, Sajini
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Chen, Jennifer Y.
United States, Boston
Brigham and Women's Hospital
Mmalane, Mompati O.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Powis, Kathleen M.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Massachusetts General Hospital
Essex, Max E.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Boston
Harvard T.h. Chan School of Public Health
Makhema, Joseph M.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
Shapiro, Roger L.
Botswana, Gaborone
Botswana Harvard Aids Institute Partnership
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Beth Israel Deaconess Medical Center
Statistics
Citations: 40
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1016/j.ijgo.2011.04.008
ISSN:
00207292
e-ISSN:
18793479
Research Areas
Infectious Diseases
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Botswana
Participants Gender
Female