Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Outcome of cervical intraepithelial neoplasia 2 diagnosed by punch biopsy in 131 women
Journal of Obstetrics and Gynaecology Research, Volume 37, No. 7, Year 2011
Notification
URL copied to clipboard!
Description
Aim: To study the outcome of biopsy-diagnosed cervical intraepithelial neoplasia (CIN) 2 in patients treated by loop electrosurgical excision procedure (LEEP) or cold knife cone biopsy (CKC). Material and Methods: Patients (n = 131) were analyzed for histological results on LEEP/CKC specimen. Demographic and risk factors, referral cytology, high risk human papilloma virus (HR HPV) test and follow-up colposcopic clinic visits were studied. Results: Excisional specimens from LEEP/CKC demonstrated no CIN in 20 (15%), CIN 1 in 17 (13%), CIN 2 in 57 (44%) and CIN 3 in 37 (28%). No invasive cancers were identified. The referral Pap smear was high grade or possible high grade in 52 (40%), low grade in 59 (45%) and inconclusive in 20 (15%). Fourteen patients (11%) had positive excisional margins, eight of the 14 were tested for HR HPV infection before LEEP, and all were positive. Post-treatment HPV testing was performed at the 12-month visit in 6 of the 14 patients who had positive excision margins, and all 6 tested were negative. Two women (1.5%) with clear margins had recurrence of CIN 2, both tested positive for HR HPV after treatment. Conclusion: Our data showed that a significant number of women (28%) with biopsy-diagnosed CIN 2 had CIN 1 or no dysplasia on subsequent excisional biopsy. The recurrence risk of high grade dysplasia in CIN 2 is low (1.5%). However, due to the high number of patients (72%) with high grade dysplasia at treatment biopsy, caution needs to be exercised when a conservative approach is adopted in the management of CIN 2. © 2011 The Authors.
Authors & Co-Authors
Ding, Zongqun
Australia, Sydney
Sydney Cancer Centre
Jiang, Chunping
Australia, Sydney
Sydney Cancer Centre
China
She-kou Hospital
Shore, Timothy
Australia, Sydney
Sydney Cancer Centre
Pather, Selvan
Australia, Sydney
Sydney Cancer Centre
Dalrymple, Christopher
Australia, Sydney
Sydney Cancer Centre
Atkinson, Kenneth
Australia, Sydney
Sydney Cancer Centre
Murali, Rajmohan
Australia, Sydney
Royal Prince Alfred Hospital
Al-Rayyan, Ehab Salem Yousef
Australia, Sydney
Sydney Cancer Centre
Jordan, Amman
Eking Husain Medical Center
Luo, Kehui
Australia, Sydney
Macquarie University
Carter, Jonathan R.
Australia, Sydney
Sydney Cancer Centre
Statistics
Citations: 10
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1111/j.1447-0756.2010.01427.x
ISSN:
13418076
e-ISSN:
14470756
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Participants Gender
Female