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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Anti-TNF-α therapy improves insulin sensitivity in non-diabetic patients with psoriasis: A 6-month prospective study
Journal of the European Academy of Dermatology and Venereology, Volume 29, No. 7, Year 2015
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Description
Objective Psoriasis is a chronic inflammatory disease associated with increased risk of cardiovascular death. Several studies have shown a beneficial effect of anti-TNF-α therapy on the mechanisms associated with accelerated atherogenesis in patients with inflammatory arthritis, including an improvement of insulin sensitivity. In this study, we aimed to determine for the first time whether the anti-TNF-α monoclonal antibody adalimumab may improve insulin sensitivity in non-diabetic patients with psoriasis. Methods Prospective study on a series of consecutive non-diabetic patients with moderate to severe psoriasis seen at the Dermatology Division of Hospital Universitario Marques de Valdecilla (Northern Spain) who completed 6 months of therapy with adalimumab (80 mg at week 0 followed by 40 mg every other week, starting 1 week after the initial dose). Patients with chronic kidney disease, hypertension or body mass index ≥ 35 kg/m2 were excluded. Metabolic and clinical evaluation including assessment of insulin sensitivity using the Quantitative Insulin Sensitivity Check Index (QUICKI) was performed at the onset of the treatment (time 0) and at month 6. Results Twenty-nine patients (52% women; 38.6 ± 10.7 years) with moderate to severe psoriasis [body surface area (BSA) 37.9 ± 16.3%], Psoriasis Area and Severity Index [(PASI) 18.9 ± 7.8] were assessed. Statistically significant improvement (P=0.008) of insulin sensitivity was observed after 6 months of adalimumab therapy (QUICKI at time 0: 0.35 ± 0.04 vs. 0.37 ± 0.04 at month 6). Significant improvement of erythrocyte sedimentation rate, ultrasensitive C-reactive protein, BSA, PASI, Nail Psoriasis Severity Index, physician global assessment and psoriatic arthritis screening and evaluation questionnaire was also observed at month 6 (P < 0.05 for each variable). Conclusion Our results support a beneficial effect of the anti-TNF-α blockade on the mechanisms associated with accelerated atherogenesis in patients with psoriasis. © 2014 European Academy of Dermatology and Venereology.
Authors & Co-Authors
Piña, Trinitario
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Alonso, Susana Armesto
Spain, Santander
Hospital Universitario Marqués de Valdecilla
López-Mejías, Raquel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Genre, Fernanda
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Ubilla, Begoña
Spain, Santander
Hospital Universitario Marqués de Valdecilla
González-Vela, María Carmen
Spain, Santander
Universidad de Cantabria
Corrales, Alfonso F.
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Blanco-Alonso, Ricardo
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Unzueta, María Teresa García
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Herńandez, José L.
Spain, Santander
Universidad de Cantabria
Llorca-Díaz, Javier Francisco
Spain, Santander
Universidad de Cantabria
González-Gay, Miguel Ángel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Statistics
Citations: 60
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1111/jdv.12814
ISSN:
09269959
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female