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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The influence of age on the outcome of treatment of elderly patients with colorectal cancer
Journal of Geriatric Oncology, Volume 5, No. 2, Year 2014
Notification
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Description
Objectives: We investigated factors associated with post-operative mortality rates in those aged ≥ 60, and in particular, the relative survival of age bands within this group. Methods: Secondary analysis of a large comprehensive cohort of the elderly treated for colorectal cancer in the North of England during 1998-2003. We investigated seven risk factors associated with 30-day and 6-month post-operative mortality from colorectal surgery. Results: 6083 patients aged ≥ 60 underwent colorectal cancer surgery. Approximately 8% had died within 30. days of surgery and 17% had died within 6. months. Thirty-day mortality was greater in the elderly (80. years. +) compared to the young-old (60-69. years) (adjusted OR: 3.2, 95% CI 2.4 to 4.4). There was neither a significant difference between the proportions offered curative resections across the age-groups, nor was there a significant association between intent of surgery and 30-day mortality. Six-month mortality rose with age, but the association was stronger in those having curative surgery (adjusted OR: 3.8, 95% CI 2.8 to 5.2) than palliative surgery (adjusted OR: 1.5, 95% CI 1.1 to 2.1). Mortality from emergency surgery at 6-months was particularly high in elderly females. Conclusions: This large population study adds more weight to the findings that age itself is a major risk factor in the outcome of colorectal surgery in elderly and that 30-day mortality underestimates the longer-term outcome in this age group. There was no significant association between radical resections and 30-day mortality in elderly patients compared to the younger age groups; however, a disproportionately higher mortality at 6. months was seen in elderly female patients. © 2014 Elsevier Inc.
Authors & Co-Authors
Ahmed, Sohail
United Kingdom, Darlington
Darlington Memorial Hospital
Howel, Denise
United Kingdom, Newcastle
University of Newcastle Upon Tyne, Faculty of Medical Sciences
Debrah, Samuel Akobour Yaw
United Kingdom, Darlington
Darlington Memorial Hospital
Ghana, Cape Coast
University of Cape Coast Ghana
Statistics
Citations: 19
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1016/j.jgo.2013.12.005
ISSN:
18794068
e-ISSN:
18794076
Research Areas
Cancer
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female