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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Low-coverage vaccination strategies for the conservation of endangered species
Nature, Volume 443, No. 7112, Year 2006
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Description
The conventional objective of vaccination programmes is to eliminate infection by reducing the reproduction number of an infectious agent to less than one, which generally requires vaccination of the majority of individuals. In populations of endangered wildlife, the intervention required to deliver such coverage can be undesirable and impractical; however, endangered populations are increasingly threatened by outbreaks of infectious disease for which effective vaccines exist. As an alternative, wildlife epidemiologists could adopt a vaccination strategy that protects a population from the consequences of only the largest outbreaks of disease. Here we provide a successful example of this strategy in the Ethiopian wolf, the world's rarest canid, which persists in small subpopulations threatened by repeated outbreaks of rabies introduced by domestic dogs. On the basis of data from past outbreaks, we propose an approach that controls the spread of disease through habitat corridors between subpopulations and that requires only low vaccination coverage. This approach reduces the extent of rabies outbreaks and should significantly enhance the long-term persistence of the population. Our study shows that vaccination used to enhance metapopulation persistence through elimination of the largest outbreaks of disease requires lower coverage than the conventional objective of reducing the reproduction number of an infectious agent to less than one. © 2006 Nature Publishing Group.
Authors & Co-Authors
Haydon, Daniel Thomas
United Kingdom, Glasgow
University of Glasgow
Randall, Deborah A.
United Kingdom, Oxford
University of Oxford
Ethiopia, Robe
Ethiopian Wolf Conservation Programme
Matthews, Louise
United Kingdom, Roslin
The Royal Dick School of Veterinary Studies
Knobel, Darryn L.
Ethiopia, Robe
Ethiopian Wolf Conservation Programme
United Kingdom, Roslin
The Royal Dick School of Veterinary Studies
Tallents, Lucy A.
United Kingdom, Oxford
University of Oxford
Ethiopia, Robe
Ethiopian Wolf Conservation Programme
Gravenor, Mike B.
United Kingdom, Swansea
Swansea University Medical School
Williams, Stuart D.
United Kingdom, Oxford
University of Oxford
Ethiopia, Robe
Ethiopian Wolf Conservation Programme
Pollinger, John P.
United States, Los Angeles
University of California, Los Angeles
Cleaveland, Sarah C.
United Kingdom, Roslin
The Royal Dick School of Veterinary Studies
Woolhouse, Mark E.J.
United Kingdom, Edinburgh
The University of Edinburgh
Sillero-Zubiri, Claudio
United Kingdom, Oxford
University of Oxford
Ethiopia, Robe
Ethiopian Wolf Conservation Programme
Marino, Jorgelina
United Kingdom, Oxford
University of Oxford
Ethiopia, Robe
Ethiopian Wolf Conservation Programme
Macdonald, David W.
United Kingdom, Oxford
University of Oxford
Laurenson, M. Karen
Ethiopia, Robe
Ethiopian Wolf Conservation Programme
United Kingdom, Roslin
The Royal Dick School of Veterinary Studies
Tanzania, Arusha
Frankfurt Zoological Society Arusha
Statistics
Citations: 189
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1038/nature05177
ISSN:
00280836
e-ISSN:
14764687
Research Areas
Health System And Policy
Study Design
Randomised Control Trial
Cross Sectional Study