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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity
Immunity, Volume 36, No. 1, Year 2012
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Description
C-type lectin receptors (CLRs) that couple with the kinase Syk are major pattern recognition receptors for the activation of innate immunity and host defense. CLRs recognize fungi and other forms of microbial or sterile danger, and they induce inflammatory responses through the adaptor protein Card9. The mechanisms relaying CLR proximal signals to the core Card9 module are unknown. Here we demonstrated that protein kinase C-δ (PKCδ) was activated upon Dectin-1-Syk signaling, mediated phosphorylation of Card9 at Thr231, and was responsible for Card9-Bcl10 complex assembly and canonical NF-κB control. Prkcd -/- dendritic cells, but not those lacking PKCα, PKCβ, or PKCθ, were defective in innate responses to Dectin-1, Dectin-2, or Mincle stimulation. Moreover, Candida albicans-induced cytokine production was blocked in Prkcd -/- cells, and Prkcd -/- mice were highly susceptible to fungal infection. Thus, PKCδ is an essential link between Syk activation and Card9 signaling for CLR-mediated innate immunity and host protection. © 2012 Elsevier Inc.
Authors & Co-Authors
Strasser, Dominikus
Germany, Munich
Klinikum Rechts Der Isar
Neumann, Konstantin
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Bergmann, Hanna
Germany, Munich
Klinikum Rechts Der Isar
Marakalala, Mohlopheni Jackson
South Africa, Cape Town
Faculty of Health Sciences
Guler, Reto
South Africa, Cape Town
Faculty of Health Sciences
South Africa, Cape Town
University of Cape Town
Rojowska, Anna
Germany, Munich
Ludwig-maximilians-universität München
Hopfner, Karl Peter
Germany, Munich
Ludwig-maximilians-universität München
Brombacher, Frank
South Africa, Cape Town
Faculty of Health Sciences
South Africa, Cape Town
University of Cape Town
Urlaub, Henning
Germany, Gottingen
Max Planck Institute for Biophysical Chemistry
Germany, Gottingen
Universitätsmedizin Göttingen
Baier, Gottfried
Austria, Innsbruck
Medizinische Universitat Innsbruck
Brown, Gordon D.A.
South Africa, Cape Town
Faculty of Health Sciences
United Kingdom, Aberdeen
University of Aberdeen School of Medicine, Medical Sciences and Nutrition
Leitges, Michael
Norway, Oslo
Universitetet I Oslo
Ruland, Jürgen
Germany, Munich
Klinikum Rechts Der Isar
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Statistics
Citations: 242
Authors: 13
Affiliations: 10
Identifiers
Doi:
10.1016/j.immuni.2011.11.015
ISSN:
10747613