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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Linking African ancestral substructure to prostate cancer health disparities
Scientific Reports, Volume 13, No. 1, Article 20909, Year 2023
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Description
Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking within the continent and as such exclude for significant ancestral diversity. Here, we investigate a series of epidemiological demographic and lifestyle risk factors for 1387 men recruited as part of the multi-ethnic Southern African Prostate Cancer Study (SAPCS). We found poverty to be a decisive factor for disease grade and age at diagnosis, with other notably significant PCa associated risk factors including sexually transmitted diseases, erectile dysfunction, gynaecomastia, and vertex or complete pattern balding. Aligned with African American data, Black ethnicity showed significant risk for PCa diagnosis (OR = 1.44, 95% CI 1.05–2.00), and aggressive disease presentation (ISUP ≥ 4: OR = 2.25, 95% CI 1.49–3.40). New to this study, we demonstrate African ancestral population substructure associated PCa disparity, observing increased risk for advanced disease for the southern African Tsonga people (ISUP ≥ 4: OR = 3.43, 95% CI 1.62–7.27). Conversely, South African Coloured were less likely to be diagnosed with aggressive disease overall (ISUP ≥ 3: OR = 0.38, 95% 0.17–0.85). Understanding the basis for PCa health disparities calls for African inclusion, however, lack of available data has limited the power to begin discussions. Here, focusing on arguably the largest study of its kind for the African continent, we draw attention to the contribution of within African ancestral diversity as a contributing factor to PCa health disparities within the genetically diverse region of southern Africa. © 2023, The Author(s).
Authors & Co-Authors
Gheybi, Kazzem
Australia, Sydney
The University of Sydney
Lebelo, Maphuti Tebogo
South Africa, Pretoria
University of Pretoria
Patrick, Sean Mark
South Africa, Pretoria
University of Pretoria
Campbell, Raymond
Unknown Affiliation
Soh, Pamela X.Y.
Australia, Sydney
The University of Sydney
Obida, Muvhulawa
South Africa, Pretoria
University of Pretoria
Loda, Massimo F.
United States, New York
Weill Cornell Medicine
Butler, Eboneé N.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Mutambirwa, Shingai Bertrand Angelo
South Africa, Pretoria
Sefako Makgatho Health Sciences University Smu
Bornman, M. S.Riana
South Africa, Pretoria
University of Pretoria
Hayes, Vanessa M.
Australia, Sydney
The University of Sydney
South Africa, Pretoria
University of Pretoria
South Africa, Sovenga
University of Limpopo
Statistics
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1038/s41598-023-47993-x
ISSN:
20452322
Research Areas
Cancer
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Participants Gender
Male