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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major Infection
PLoS Neglected Tropical Diseases, Volume 7, No. 10, Article e2478, Year 2013
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Description
Background:Leishmania (L.) are intracellular protozoan parasites able to survive and replicate in the hostile phagolysosomal environment of infected macrophages. They cause leishmaniasis, a heterogeneous group of worldwide-distributed affections, representing a paradigm of neglected diseases that are mainly embedded in impoverished populations. To establish successful infection and ensure their own survival, Leishmania have developed sophisticated strategies to subvert the host macrophage responses. Despite a wealth of gained crucial information, these strategies still remain poorly understood. MicroRNAs (miRNAs), an evolutionarily conserved class of endogenous 22-nucleotide non-coding RNAs, are described to participate in the regulation of almost every cellular process investigated so far. They regulate the expression of target genes both at the levels of mRNA stability and translation; changes in their expression have a profound effect on their target transcripts.Methodology/Principal Findings:We report in this study a comprehensive analysis of miRNA expression profiles in L. major-infected human primary macrophages of three healthy donors assessed at different time-points post-infection (three to 24 h). We show that expression of 64 out of 365 analyzed miRNAs was consistently deregulated upon infection with the same trends in all donors. Among these, several are known to be induced by TLR-dependent responses. GO enrichment analysis of experimentally validated miRNA-targeted genes revealed that several pathways and molecular functions were disturbed upon parasite infection. Finally, following parasite infection, miR-210 abundance was enhanced in HIF-1α-dependent manner, though it did not contribute to inhibiting anti-apoptotic pathways through pro-apoptotic caspase-3 regulation.Conclusions/Significance:Our data suggest that alteration in miRNA levels likely plays an important role in regulating macrophage functions following L. major infection. These results could contribute to better understanding of the dynamics of gene expression in host cells during leishmaniasis. © 2013 Lemaire et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s002.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s003.tiff
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s004.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s005.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s006.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s007.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s008.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s009.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s010.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s011.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s012.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s013.xls
https://efashare.b-cdn.net/share/pmc/articles/PMC3789763/bin/pntd.0002478.s014.xls
Authors & Co-Authors
Lemaire, Julien
Belgium, Namur
Namur Research Institute for Life Sciences
Mkannez, Ghada
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Guerfali, Fatma Zahra
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Gustin, Cindy
Belgium, Namur
Namur Research Institute for Life Sciences
Attia, Hanène
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Sghaier, Rabiaa Manel
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Ben Miled, Slimane
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Benkahla, Alia
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Ben-Othman, Rym
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Bruno, Roman
France, Montpellier
Skuldtech
Cazenave, Pierre André
France, Paris
Laboratoire Jacques-louis Lions
Checkmeneva, Elena
Germany, Wolfenbuttel
Biobase Gmbh
Daskalaki, Adriani
Germany, Wolfenbuttel
Biobase Gmbh
Gabdoulline, Razif
Germany, Wolfenbuttel
Biobase Gmbh
Ghedira, Kaïs
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Guzani-Tabbane, Lamia
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Herwig, Ralf
Germany, Berlin
Max Planck Institute for Molecular Genetics
Hide, Winston A.
South Africa, Bellville
University of the Western Cape
United States, Boston
Harvard T.h. Chan School of Public Health
Hofmann, Oliver M.
South Africa, Bellville
University of the Western Cape
United States, Boston
Harvard T.h. Chan School of Public Health
Hornischer, Klaus
Germany, Wolfenbuttel
Biobase Gmbh
Jauregui, Ruy
Germany, Wolfenbuttel
Biobase Gmbh
Kel, Alexander
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Kiselev, Ilya
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Kolpakov, Fedor A.
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Kondrakhin, Yuriy
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Kutumova, Elena
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Land, Sigrid
Germany, Wolfenbuttel
Biobase Gmbh
Liebich, Ines
Germany, Wolfenbuttel
Biobase Gmbh
Manchon, Laurent
France, Montpellier
Skuldtech
Matys, Volker
Germany, Wolfenbuttel
Biobase Gmbh
Michael, Holger
Germany, Wolfenbuttel
Biobase Gmbh
Noguier, Florian
France, Montpellier
Skuldtech
Pierrat, Fabien
France, Montpellier
Skuldtech
Piquemal, D.
France, Montpellier
Skuldtech
Rabhi, Imen
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Rabhi, Sameh
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Rasche, Axel
Germany, Berlin
Max Planck Institute for Molecular Genetics
Regnault, Béatrice
France, Paris
Institut Pasteur, Paris
Ryabova, Anna
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Schacherer, Frank
Germany, Wolfenbuttel
Biobase Gmbh
Sharipov, Ruslan N.
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Stegmaier, Philip
Germany, Wolfenbuttel
Biobase Gmbh
Tiffin, Nicki T.
South Africa, Bellville
University of the Western Cape
Tolstykh, Nikita
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Trentin, Bernadette
France, Montpellier
Skuldtech
Valeev, Tagir
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Voss, Nico
Germany, Wolfenbuttel
Biobase Gmbh
Wierling, Christoph
Germany, Berlin
Max Planck Institute for Molecular Genetics
Yevshin, Ivan S.
Russian Federation, Novosibirsk
Institute of Systems Biology, Ltd
Dellagi, Koussey
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
France, Marseille
Ird Institut de Recherche Pour le Developpement
Laouini, Dhafer
Tunisia, Tunis
Institut Pasteur de Tunis
Tunisia, Tunis
Université de Tunis el Manar
Renard, Patricia
Belgium, Namur
Namur Research Institute for Life Sciences
Statistics
Citations: 92
Authors: 52
Affiliations: 12
Identifiers
Doi:
10.1371/journal.pntd.0002478
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Genetics And Genomics